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Phospho-SAMHD1 (Thr592) Rabbit Polyclonal Antibody#abs138005

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Description

Catalog-specification	Delivery time	USD price
abs138005-100ug	1-2 Weeks	301.0
abs138005-50ug	1-2 Weeks	201.0

Overview
catalog	abs138005
Other names	I apologize, but I cannot rearrange the given content to generate highly similar content.
Source	Rabbit
Specificity	The detection of endogenous levels of SAMHD1 is accomplished by the Phospho-SAMHD1 (Thr592) Antibody, which specifically recognizes SAMHD1 only when it is phosphorylated at Thr592. By targeting this specific phosphorylation event, the antibody allows researchers to measure the presence of phosphorylated SAMHD1 in biological samples.
Species Reactivity	Human
Antigen	SAMHD1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	Closely resembling the original text information, a peptide synthesized from Thr592 of human Phospho-SAMHD1 has been developed. The derived peptide bears a high structural similarity to the mentioned amino acid residue, ensuring an accurate representation of the original biological information.
MW	72KD
Properties
Concentration	1mg/ml
purification	The antibody was obtained by purifying rabbit serum through affinity purification involving consecutive chromatography on phospho- and non-phospho-peptide affinity columns. Please note that the content generated should be highly similar to the original text but rearranged to meet the requirements.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at -20 °C for up to a year. To avoid any potential damage caused by repeated freezing and thawing, it's important to keep it stablized at -20 °C.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling (PubMed:18546154, PubMed:19525956, PubMed:22056990, PubMed:24336198, PubMed:28229507). Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction (PubMed:25038827).
Tissue specificity	Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.
Posttranslational modification	Ubiquitinated and targeted for proteasomal degradation by a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase with the help of the viral accessory protein Vpx.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	Q9Y3Z3