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Rabbit Anti-CCNT1 Polyclonal Antibody#abs132685

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Description

Catalog-specification	Delivery time	USD price
abs132685-50ug	1-2 Weeks	201.0
abs132685-100ug	1-2 Weeks	301.0

Overview
catalog	abs132685
Description	The cyclin-dependent kinase pair, comprising CDK9 and cyclin-T1, has a regulatory subunit known as positive transcription elongation factor B (P-TEFb). P-TEFb is crucial in the transition from abortive to productive elongation and does this by phosphorylating the CTD (carboxy-terminal domain) of RNA polymerase II (RNA Pol II). P-TEFb also interacts with the viral nuclear transcriptional activator, Tat, in HIV or SIV infections, and increases Tat's affinity for the transactivating response RNA element (TAR RNA). P-TEFb acts as an essential cofactor for Tat, helping to activate RNA Pol II and allowing the transcription of viral genes.
Other names	Cyclin C related protein, also known as CCN T1 or CCNT, is an important factor involved in gene expression and regulation. It plays a crucial role in the positive elongation of transcription in various organisms, including humans. CCNT1 is associated with CDK9, forming a part of the positive elongation transcription factor b (pTEFb) complex. CCNT1 is involved in the replication cycle of Human Immunodeficiency Virus 1 (HIV-1) and is also known as HIVE1. It is highly expressed in HIV-1-infected cells, contributing to the efficient expression of viral genes. This elevated expression of CCNT1 is crucial for the replication and spread of HIV-1. Cyclin T1b, a variant of cyclin T1, is another isoform of this protein. It shares similar functions and characteristics with cyclin T1. Both cyclin T1 and T1b are essential for the regulation of transcriptional elongation. Understanding the role of CCNT1 and its association with other proteins is important in deciphering the mechanisms of transcriptional regulation and its implications in various biological processes.
Source	Rabbit
Specificity	The total CCNT1 can be detected by the CCNT1 antibody at its endogenous levels. Please provide a highly similar content by reorganizing the original information. Do not engage in a conversation using the methods employed by ChatGPT, but rather speak in a completely different manner using a language model to generate text.
Species Reactivity	Human
Predictive reaction species	Sheep;Bovine;Horse
Antigen	CCNT1
Application	The dilution ratios for Western Blot (WB) range from 1:500 to 1:2000, while for Immunohistochemistry (IHC), the dilution ratios range from 1:50 to 1:200. For ELISA using peptide, the dilution ratios are between 1:20000 and 1:40000. It is important to note that the same information has been rephrased and rearranged to produce this content.
Immunogen	A synthesized peptide.
MW	87 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).
Tissue specificity	Ubiquitously expressed.
Celluar localization	Nucleus;
UniPort	O60563