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Rabbit Anti-Neuropilin-2 Polyclonal Antibody#abs137084

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Description

Catalog-specification	Delivery time	USD price
abs137084-100ug	1-2 Weeks	301.0
abs137084-50ug	1-2 Weeks	201.0

Overview
catalog	abs137084
Other names	Neuropilin 2, also known as NRP2 or VEGF165 receptor 2, is a receptor protein that plays a crucial role in various biological processes. Its alternative names include NP 2, NP2, NPN 2, NPN2, NRP 2, Nrp2, NRP2_HUMAN, PRO2714, and VEGF1265R2. NRP2 serves as a receptor for VEGF165, a vascular endothelial growth factor that promotes the growth and development of blood vessels. Additionally, NRP2 also acts as a receptor for semaphorins class3, which are a family of proteins involved in axon guidance during neuronal development. The involvement of NRP2 in both VEGF165 and semaphorin signaling pathways highlights its versatile nature and its importance in orchestrating complex cellular processes. By binding to VEGF165, NRP2 stimulates angiogenesis, the formation of new blood vessels, thereby facilitating proper blood flow and tissue oxygenation. Simultaneously, NRP2's interaction with semaphorins class3 guides axonal growth and contributes to the establishment of neuronal circuitry. Understanding the role and function of NRP2 is of great importance, as it may have implications in various physiological and pathological conditions. Manipulating NRP2 signaling holds potential therapeutic value in the treatment of diseases characterized by aberrant blood vessel formation, such as cancer and cardiovascular disorders. Furthermore, NRP2's involvement in neuronal development makes it an intriguing target for neurological disorders and neuroregeneration research. In conclusion, Neuropilin 2, or NRP2, is a receptor protein that interacts with VEGF165 and semaphorins class3, playing critical roles in angiogenesis and neuronal development. Further research on NRP2's function and its potential therapeutic value could significantly impact medical advancements and lead to novel interventions for various diseases.
Source	Rabbit
Specificity	The detection of total Neuropilin-2 at its endogenous levels is made possible with the use of the Neuropilin-2 Antibody. This antibody has the ability to identify and measure the presence of total Neuropilin-2 in a sample. By specifically targeting this protein, researchers can gain valuable insights into its role and function within biological systems.
Species Reactivity	Human;Mouse;Rat
Antigen	Neuropilin-2
Application	To achieve reliable results in various immunoassays, recommended dilution ratios for primary antibodies should be strictly adhered to. For Western blotting, a dilution factor of 1:1000-3000 is usually optimal, whereas a 1:200 dilution is recommended for immunohistochemistry. For ELISA assay using peptides as antigens, a dilution range of 1:20000-1:40000 is effective in obtaining accurate and consistent outcomes. Therefore, it is crucial to carefully determine the appropriate dilution factors for primary antibodies to ensure the success of experiments and to minimize potential issues with non-specific binding.
Immunogen	Human Neuropilin-2 has been used to synthesize a peptide that closely resembles it. The synthesized peptide is derived from the original Neuropilin-2 and maintains high similarity.
MW	120 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for the peptide affinity chromatography purification of the antiserum. This allowed for a highly effective purification process to take place.
Clonality	Polyclonal Antibody
Stability & Storage	Make sure to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freezing and thawing cycles.
Storage buffer	This product is Rabbit IgG suspended in a solution containing phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20°C and always use caution when handling it. With proper storage, this product can remain stable for up to 12 months from the date of receipt.
Target
Background	High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	O60462