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Rabbit Anti-FANCC Polyclonal Antibody#abs136152

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Description

Catalog-specification	Delivery time	USD price
abs136152-100ug	1-2 Weeks	301.0
abs136152-50ug	1-2 Weeks	201.0

Overview
catalog	abs136152
Description	Fanconi anemia is a rare genetic disorder characterized by chromosomal instability, increased susceptibility to DNA damage, and defective DNA repair. This disorder is caused by mutations in one of the 13 Fanconi anemia complementation group genes, including FANCA, FANCB, FANCC, FANCD1 (BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (BRIP1), FANCL, FANCM, and FANCN (PALB2). Notably, these genes do not share any sequence similarity; rather, they assemble into a common nuclear protein complex. FANCH is now subsumed under FANCA. This protein complex plays a critical role in repairing DNA damage, particularly after exposure to cross-linking agents. Mutations in any of the Fanconi anemia complementation group genes can disrupt the stability of the complex and contribute to the development of the disorder.
Other names	FANCC is a protein that belongs to the Fanconi anemia complementation group C. This protein plays an important role in DNA repair and maintenance of chromosome stability. Mutations in the FANCC gene can cause Fanconi anemia, a rare genetic disorder that affects bone marrow function and increases the risk of developing certain types of cancer. FANCC is also known as Fanconi pancytopenia type 3 and is sometimes referred to as FACC or FAC. The protein is encoded by the FLJ14675 gene and is highly conserved across species. Studying the function of FANCC is essential for understanding the pathophysiology of Fanconi anemia and developing effective therapies for this devastating disease.
Source	Rabbit
Specificity	The total FANCC levels can be effectively detected by the FANCC Antibody, which specifically targets the endogenous expression of FANCC.
Species Reactivity	Human;Mouse
Predictive reaction species	Dog
Antigen	FANCC
Application	The dilution ratios for Western blotting range from 1:500 to 1:2000, for immunohistochemistry from 1:50 to 1:200, and for ELISA using peptide from 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human FANCC.
MW	63kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
Tissue specificity	Ubiquitous.
Celluar localization	Cytosol;Nucleus;
UniPort	Q00597