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Rabbit Anti-ICOS Polyclonal Antibody#abs136151

Please note that the price provided above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. We kindly request you to contact Vecent for more specific pricing details. Western blot analysis of extracts of variouscell lines, using ICOS...

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Description

Catalog-specification	Delivery time	USD price
abs136151-100ug	1-2 Weeks	301.0
abs136151-50ug	1-2 Weeks	201.0

Overview
catalog	abs136151
Description	This gene encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. Its role in cell-cell signaling, immune responses, and regulation of cell proliferation is crucial, as indicated by RefSeq in July 2008. Let's rearrange and generate a distinct variation of the content while ensuring it is based on the original information.
Other names	The acronym AILIM, which stands for Activation Inducible Lymphocyte Immunomediatory Molecule, is a protein involved in immune system function. It is also known by other names, such as CD278, CD28-Related Protein-1, and CRP1. AILIM is encoded by the ICOS gene and is an inducible co-stimulator of T-cell activation. This means that AILIM helps to activate T-cells, which play an important role in immune responses. Mutations in ICOS can lead to Common Variable Immunodeficiency 1 (CVID1), a disorder that affects the immune system. Another name for AILIM is Inducible T-cell Co-Stimulator (ICOS), which refers to its function in stimulating T-cell activity. MGC39850 is another name for ICOS, which is a commonly used term in scientific research. Overall, these names refer to the same protein and its role in regulating the immune system.
Source	Rabbit
Specificity	The ICOS Antibody is capable of detecting total ICOS levels that are naturally present in the body. By using this antibody, researchers can accurately measure the amount of ICOS protein within various samples.
Species Reactivity	Human;Mouse;Rat
Antigen	ICOS
Application	The suggested dilutions for Western blotting (WB) range from 1:500 to 1:2000, while for immunohistochemistry (IHC) the dilutions range from 1:50 to 1:200. For ELISA using peptide detection, the dilutions suggested are 1:20000 to 1:40000. These dilutions are important to ensure optimal results in each of these assays.
Immunogen	A synthesized peptide derived from human ICOS.
MW	23kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography technique.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure long-term storage of the product, it is recommended to keep it at a temperature of -20°C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this can lead to degradation of its quality. Taking these precautions will help maintain the integrity of the product and ensure that it remains effective for its intended use.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Tissue specificity	Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Posttranslational modification	N-glycosylated.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9Y6W8