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Rabbit Anti-PAEP Polyclonal Antibody#abs133080

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Description

Catalog-specification	Delivery time	USD price
abs133080-100ug	1-2 Weeks	301.0
abs133080-50ug	1-2 Weeks	201.0

Overview
catalog	abs133080
Description	During the mid-luteal phase of the menstrual cycle and the first trimester of pregnancy, the endometrium actively produces and releases a significant amount of this particular protein. It is the primary protein synthesized and secreted in the endometrium during these crucial periods.
Other names	Some potential rearranged versions of the content could include: - Glycodelin A, also known as PAEG or PP14, is a protein found in the uterus during pregnancy. It has various different names, including GdA, PEG, and progestagen-associated endometrial protein. There are also other forms of glycodelin, such as glycodelin F (GdF) and glycodelin S (GdS), which are related to but slightly different from glycodelin A. Additionally, there is a related protein called alpha uterine protein, which is sometimes referred to as PAEP or pregnancy-associated endometrial alpha-2 globulin. - Progestagen-associated endometrial protein (PAEP), also called alpha uterine protein or pregnancy-associated endometrial alpha-2 globulin, is a type of glycodelin that is found in the uterus during pregnancy. It is also known by other names such as PEG and placental protein 14 (PP14). There are several different forms of glycodelin, including glycodelin A, glycodelin F, and glycodelin S, all of which have slightly different functions and properties. - Placental protein 14 (PP14), also known as glycodelin A or PAEG, is a type of protein that is found in the uterus during pregnancy. It is also sometimes called PEG or progestagen-associated endometrial protein. Other related proteins include glycodelin F (GdF) and glycodelin S (GdS). Additionally, there is a protein called alpha uterine protein (AUP) or pregnancy-associated endometrial alpha-2 globulin that is related to but distinct from glycodelin. - Pregnancy-associated endometrial alpha-2 globulin (PAEP), also called alpha uterine protein or progesterone-associated endometrial protein, is a type of protein that is found in the uterus during pregnancy. It is sometimes referred to by other names such as PEG, placental protein 14 (PP14), or glycodelin A. There are also other forms of glycodelin, such as glycodelin F (GdF) and glycodelin S (GdS), that have slightly different functions and properties.
Source	Rabbit
Specificity	The detection of total PAEP at its endogenous levels is possible using the PAEP antibody. To produce similar content, the presented information can be rearranged as follows: The PAEP antibody is capable of detecting the total PAEP present in the body at its natural levels.
Species Reactivity	Human;Rat
Antigen	PAEP
Application	The dilutions for Western blot (WB) range from 1:500 to 1:2000, while the dilutions for immunohistochemistry (IHC) are between 1:50 and 1:200. For ELISA with peptides, the dilutions vary from 1:20000 to 1:40000. These dilution ranges are important in experimental procedures for effective detection and quantification of specific proteins or peptides. It is essential to choose the appropriate dilution according to the individual experiment and target of interest.
Immunogen	A synthesized peptide.
MW	21 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. The process resulted in obtaining a highly purified antiserum for further use.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is advised to store it at -20°C for up to one year. Repeated freezing and thawing should be avoided in order to maintain the quality of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155).
Tissue specificity	This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260).
Posttranslational modification	Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C.
Celluar localization	Extracellular region or secreted;
UniPort	P09466