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Rabbit Anti-P2RY6 Polyclonal Antibody#abs136476

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Description

Catalog-specification	Delivery time	USD price
abs136476-100ug	1-2 Weeks	301.0
abs136476-50ug	1-2 Weeks	201.0

Overview
catalog	abs136476
Description	This gene produces a protein that belongs to the P2 receptor family, which responds to extracellular nucleotides. The P2 family can be subdivided into P2X channel receptors and P2Y G-protein coupled receptors, with multiple subtypes that have different selectivity for various adenosine and uridine nucleotides. This G-protein coupled receptor responds to UDP, partially to UTP and ADP, but not ATP. Its proposed function is to mediate inflammatory responses. Alternative splicing of this gene leads to the production of different protein isoforms.
Other names	The P2Y6 receptor, also known as P2RY6 or pyrimidinergic receptor P2Y, is a G protein coupled nucleotide receptor. It is encoded by the MGC15335 gene, also referred to as PP2891. This receptor is a member of the P2 purinoceptor family and plays a vital role in purinergic signaling. The P2Y6 receptor is responsible for mediating cellular responses to extracellular nucleotides. Its activation leads to various physiological and pathological processes. Understanding the function and regulation of the P2Y6 receptor is crucial in developing therapeutic strategies targeting this receptor for the treatment of various diseases.
Source	Rabbit
Specificity	The detection of total P2RY6 at endogenous levels can be accomplished using the P2RY6 Antibody. By rearranging the provided information, it is emphasized that the antibody is proficient in identifying the presence of total P2RY6 in an organism.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	P2RY6
Application	The dilution range for western blot (WB) is typically 1:500 to 1:1000, while for immunohistochemistry (IHC) it is 1:50 to 1:100. For immunofluorescence/immunocytochemistry (IF/ICC) the dilution range is 1:100 to 1:500, and for ELISA (peptide) it is 1:20000 to 1:40000. These dilution ranges are commonly used to optimize the concentration of antibodies for different experimental techniques. It is important to carefully select the appropriate dilution to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human P2RY6.
MW	36kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Celluar localization	Plasma Membrane;
UniPort	Q15077