Rabbit Anti-P Glycoprotein 1(MDR1) Polyclonal Antibody#abs131273
Please note that the price mentioned above is only for your reference. For the detailed pricing information, we kindly request you to get in touch with our dedicated seller, Vecent. We understand the importance of specific pricing details, and that's why we advise you to connect with our...
Description
| Catalog-specification | Delivery time | USD price |
abs131273-50ug | 1-2 Weeks | 201.0 |
abs131273-100ug | 1-2 Weeks | 301.0 |
Please note that the price mentioned above is only for your reference. For the detailed pricing information, we kindly request you to get in touch with our dedicated seller, Vecent. We understand the importance of specific pricing details, and that's why we advise you to connect with our representative to discuss the pricing in detail. We hope you find this information helpful and look forward to hearing from you soon.
| Overview | |
catalog | abs131273 |
Description | Inflammatory bowel disease (IBD) is a chronic condition characterized by recurring inflammation in the gastrointestinal tract. It has a complex cause and is divided into two main types: Crohn's disease and ulcerative colitis. Crohn's disease can affect any part of the digestive system, ranging from the mouth to the anus. However, it most commonly involves the colon and the terminal ileum. |
| Other names | MDR1 is a gene that encodes a protein called ATP-binding cassette sub-family B member 1 (ABCB1). This protein, also known as P-glycoprotein 1 (P-gp), GP170, or Multidrug resistance protein 1 (MDR1), plays a crucial role in drug resistance and transport across cell membranes. The MDR1 gene is also denoted by other names such as ABC20, CD243, CLCS, Colchicin sensitivity, Doxorubicin resistance, and PGY1. It belongs to the ATP binding cassette (ABC) transporter superfamily and is involved in the transport of a wide range of substrates, including drugs, toxins, and other molecules, out of cells. The MDR1 protein is expressed in various tissues, including the liver, intestines, kidney, and blood-brain barrier. Its expression is particularly important in protecting cells from the harmful effects of xenobiotics and promoting the elimination of drugs from the body. Mutations or alterations in the MDR1 gene can lead to increased drug resistance and reduced drug efficacy. This can have implications in the treatment of various diseases, such as cancer, where chemotherapeutic drugs may be rendered less effective due to the overexpression of MDR1. Understanding the role of MDR1 and its mechanisms of action can provide valuable insights into drug resistance and may contribute to the development of strategies to overcome it. Ongoing research in this field aims to identify potential inhibitors of MDR1 and optimize drug design to bypass its efflux function. In conclusion, MDR1 is a critical gene that encodes the P-glycoprotein 1 transporter, which plays a crucial role in multidrug resistance and drug transport. Further studies on MDR1 function and regulation are essential for improving therapeutic outcomes and developing effective treatment approaches. |
| Source | Rabbit |
| Specificity | The P Glycoprotein 1 (MDR1) Antibody is designed to specifically recognize and measure the expression levels of endogenous total P Glycoprotein 1 (MDR1) within biological samples. This antibody enables researchers to study the distribution and functional activity of P Glycoprotein 1 (MDR1) in various biological systems. By detecting the endogenous levels of P Glycoprotein 1 (MDR1), scientists can gain valuable insights into its role in drug resistance and transportation mechanisms. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Rabbit;Dog; |
| Antigen | P Glycoprotein 1 |
| Application | The dilution range for WB is 1/500-1/1000, for IHC it is 1:50-1:200, and for ELISA(peptide) it is 1:20000-1:40000. |
| Immunogen | A peptide synthesized from the P Glycoprotein 1 of humans (MDR1) has been developed. The aim was to create a compound that closely resembles the original protein. The synthesized peptide could potentially have many applications such as in drug delivery or as a therapeutic agent in cancer treatment. The peptide was carefully designed with high precision to ensure maximum efficiency and safety in its intended use. The development of this peptide marks a significant step forward in the field of proteomics and bioengineering. |
| MW | 141 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Tissue specificity | Expressed in liver, kidney, small intestine and brain. |
| Celluar localization | Extracellular region or secreted;Plasma Membrane; |
| UniPort | P08183 |
Western blot analysis MDR1 using HT-29 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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