Rabbit Anti-OPRK1 Polyclonal Antibody#abs135346
Please note that the price mentioned above is only for reference. For more information on the actual price, we kindly ask you to contact our seller, Vecent. Rest assured that Vecent will be able to provide you with all the necessary details. Thank you! This product is for research use only, not...
Description
| Catalog-specification | Delivery time | USD price |
abs135346-100ug | 1-2 Weeks | 301.0 |
abs135346-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for reference. For more information on the actual price, we kindly ask you to contact our seller, Vecent. Rest assured that Vecent will be able to provide you with all the necessary details. Thank you!
| Overview | |
catalog | abs135346 |
| Other names | K-OR-1, also known as Kappa opioid receptor or Kappa type opioid receptor, is a protein involved in the regulation of pain and reward pathways. It is encoded by the OPRK1 gene and commonly referred to as KOR or KOR-1. This receptor exhibits affinity for kappa opioids and plays a role in mediating the analgesic effects of these compounds. OPRK1, or Opiate receptor kappa 1, is one of the members of the opioid receptor family. It is widely expressed in the central nervous system, particularly in regions involved in pain perception and addiction. Activation of K-OR-1 leads to the inhibition of adenylate cyclase and the opening of potassium channels, resulting in neuronal hyperpolarization and reduced neurotransmitter release. The Kappa opioid receptor is implicated in various physiological and pathological processes, including pain modulation, stress response, mood regulation, and drug addiction. By modulating the release of neurotransmitters such as dopamine and serotonin, K-OR-1 can influence the rewarding and aversive properties of certain drugs, contributing to their addictive potential. Studies have also revealed potential therapeutic implications of targeting Kappa opioid receptors. Selective KOR agonists have shown promise in alleviating pain without the side effects associated with traditional opioid analgesics, such as respiratory depression and tolerance development. Additionally, KOR antagonists have demonstrated efficacy in attenuating withdrawal symptoms and drug-seeking behavior in preclinical models of addiction. In summary, the Kappa opioid receptor, represented by OPRK1, plays a critical role in pain and reward regulation. Understanding its function and pharmacology may pave the way for the development of novel treatments for pain and addiction disorders. |
| Source | Rabbit |
| Specificity | The OPRK1 Antibody is capable of recognizing the total amount of endogenous OPRK1. Similarly, one could generate content that conveys the same information by rearranging the given text. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | OPRK1 |
| Application | The dilution range for Western Blot (WB) is 1:500 to 1:1000. For Immunofluorescence (IF) or Immunocytochemistry (ICC), the dilution range is 1:100 to 1:500. In ELISA assays using peptides, the recommended dilution range is 1:20000 to 1:40000. These dilution ranges are crucial for obtaining accurate and reliable results in these experimental techniques. |
| Immunogen | A synthesized peptide. |
| MW | 48 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | Through the use of SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this could potentially compromise its integrity and efficacy. Therefore, proper storage procedures should be strictly adhered to in order to maintain the quality and potency of the product over time. |
| Storage buffer | This particular product contains Rabbit IgG, which is suspended in a solution of phosphate buffered saline with a pH of 7.4. Additionally, it includes 150 millimolars of sodium chloride and 0.02 percent of sodium azide, along with 50 percent glycerol. In order to ensure the integrity of the product, it needs to be stored at a temperature of -20 degrees Celsius. It is important to note that this product will remain viable for a period of 12 months from the date of receipt. |
Target | |
Background | G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
| Tissue specificity | Detected in brain and placenta. |
| Celluar localization | Plasma Membrane; |
| UniPort | P41145 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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