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Rabbit Anti-NRL Polyclonal Antibody#abs134528

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Description

Catalog-specification	Delivery time	USD price
abs134528-100ug	1-2 Weeks	301.0
abs134528-50ug	1-2 Weeks	201.0

Overview
catalog	abs134528
Other names	The NRL gene, also known as D14S46E, encodes for the Neural retina-specific leucine zipper protein, which is also referred to as NRL_MAF and RP27. This protein plays an essential role in the development and maintenance of the neural retina, specifically in the regulation of photoreceptor gene expression. NRL is a transcription factor that binds to the promoter regions of specific genes that are involved in photoreceptor development and differentiation. Therefore, mutations or abnormalities of the NRL gene can lead to various retinal degenerative disorders, including retinitis pigmentosa and cone dystrophies. The NRL protein has also been identified as a potential therapeutic target for the treatment of these degenerative diseases.
Source	Rabbit
Specificity	Endogenous levels of total NRL can be detected using the NRL Antibody
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Sheep;Bovine;Horse;Rabbit
Antigen	NRL
Application	ELISA (peptide) has a recommended dilution range of 1:20000-1:40000, while for WB, the suggested dilution is 1:500~1:1000. For IF/ICC, the optimal dilution range is 1:100-1:500. It is important to note that these dilutions are based on the original text information and are provided as a guide for researchers.
Immunogen	A synthesized peptide.
MW	26 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar content can be generated by rearranging the sentence structure while keeping the original information intact.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure preservation, it is important to store at -20°C for a period of one year. It is recommended to avoid the repeated freeze/thaw cycles in order to maintain the effectiveness of the storage.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that this antibody is stable for 12 months from the date of receipt.
Target
Background	Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.
Tissue specificity	Neural retina.
Posttranslational modification	Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation (By similarity).
Celluar localization	Cytosol;Nucleus;
UniPort	P54845