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Rabbit Anti-NOC2L Polyclonal Antibody#abs134564

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent. Western blot analysis of extracts from MCF-7 cells, using NOC2L antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs134564-100ug	1-2 Weeks	301.0
abs134564-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent.

Overview
catalog	abs134564
Other names	The protein known as NOC2L, or Nucleolar Complex associated 2 Homolog, is a transcriptional repressor that is involved in the regulation of gene expression. It is also referred to as Novel INHAT (Inhibitor of Histone Acetyltransferase) Repressor, as it is known to inhibit the activity of histone acetyltransferase, an enzyme involved in the modification of chromatin and gene expression. NOC2L is part of the NOC2-like family of proteins, which are associated with the nucleolus, a subnuclear structure involved in ribosome biogenesis. It has also been shown to interact with protein phosphatase 1, a regulatory subunit involved in the regulation of various cellular processes. The NOC2L protein is highly conserved across different species, including humans and yeast. It is involved in the regulation of various cellular processes, including cell proliferation and differentiation. It is also implicated in the regulation of various diseases, including cancer, through its role in regulating gene expression. Overall, the NOC2L protein is an important player in the regulation of gene expression and cellular processes, and its study may help to shed light on various diseases and their underlying molecular mechanisms.
Source	Rabbit
Specificity	The NOC2L Antibody is capable of detecting the total levels of endogenous NOC2L in a sample. The content remains true to the original text but has been rephrased for greater clarity.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Bovine;Horse;Rabbit
Antigen	NOC2L
Application	For Western blotting, the recommended dilution range is 1:500 to 1:1000, while for immunofluorescence and immunocytochemistry, the recommended range is 1:100 to 1:500. For ELISA assays using peptide antigens, the recommended dilution range is 1:20000 to 1:40000. It is important to note that these dilution ranges may vary depending on the specific antibody being used, and optimization may be necessary for best results.
Immunogen	A synthesized peptide.
MW	85 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we performed peptide affinity chromatography to purify the antiserum. The resulting purified antiserum is highly specific and effective in its intended use.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for up to one year. However, it is important to avoid any instances of repeated freezing and thawing, as these can damage the product and compromise its quality. So please handle the product carefully and follow the storage instructions to maintain its stability and effectiveness.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
Tissue specificity	Up-regulated by IL4 and CD40L in B-cells.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9Y3T9