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Rabbit Anti-IL22RA2 Polyclonal Antibody#abs139627

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Description

Catalog-specification	Delivery time	USD price
abs139627-100ug	1-2 Weeks	301.0
abs139627-50ug	1-2 Weeks	201.0

Overview
catalog	abs139627
Other names	IL-22 receptor subunit alpha 2 (IL-22RA2), also known as IL-22R-alpha-2 or IL22BP, is a member of the class II cytokine receptor family. It is encoded by the IL22RA2 gene and plays a crucial role in the immune system. IL-22RA2 binds with IL-22, a pro-inflammatory cytokine, and regulates its signaling pathway. This receptor is also involved in various biological processes, including tissue repair and protection against pathogens. IL-22RA2 is soluble, meaning it can exist as a free protein in the extracellular environment. It is expressed in multiple tissues and cells, such as the gastrointestinal tract, skin, and immune cells. IL-22RA2 binds to IL-22, preventing it from interacting with its cellular receptor IL-22RA1. This interaction modulates the activity of IL-22, preventing excessive immune responses and maintaining immune homeostasis. IL-22RA2 is a potential therapeutic target for inflammatory and autoimmune diseases as well as certain types of cancer. Further research is warranted to explore the full extent of IL-22RA2's functions and potential applications in medicine.
Source	Rabbit
Specificity	The total IL22RA2 is detected by the IL22RA2 Antibody, which can accurately measure the endogenous levels of IL22RA2.
Species Reactivity	Human
Antigen	IL22RA2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IL22RA2.
MW	31 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. The obtained content has the same information but is presented in a rearranged manner.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to avoid repeated freeze/thaw cycles and store the product at -20 °C for a duration of one year.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Tissue specificity	Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.
Celluar localization	Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	Q969J5