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Rabbit Anti-N4BP1 Polyclonal Antibody#abs134524

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Description

Catalog-specification	Delivery time	USD price
abs134524-100ug	1-2 Weeks	301.0
abs134524-50ug	1-2 Weeks	201.0

Overview
catalog	abs134524
Other names	KIAA0615, also known as FLJ31821, is a human protein encoded by the N4BP1 gene. It has an alternative name, MGC176730. N4BP1 is a crucial protein that binds to NEDD4, a known regulator of protein degradation. Therefore, N4BP1 is commonly referred to as NEDD4-binding protein 1. It plays an essential role in various cellular processes and is of significant interest in the field of molecular biology.
Source	Rabbit
Specificity	Total N4BP1 can be detected by the N4BP1 Antibody at its endogenous levels.
Species Reactivity	Human
Predictive reaction species	Pig
Antigen	N4BP1
Application	：/1:100-1:500，/1:500~1:1000，（）1:20000-1:40000。，。
Immunogen	A synthesized peptide.
MW	100 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography purification of the antiserum. Through this process, a highly refined end product was achieved.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this can compromise its stability and effectiveness. Take care to follow these storage guidelines to ensure that the product remains viable and effective for its intended use.
Storage buffer	This Rabbit IgG solution is formulated in phosphate buffered saline with a pH of 7.4, 150 millimolar concentration of sodium chloride, and contains 0.02% sodium azide to prevent bacterial growth. The solution is also fortified with 50% glycerol as a stabilizer. It is recommended to store this solution at a temperature below -20°C for best stability, and it will remain viable for up to 12 months from the date of receipt.
Target
Background	Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).
Tissue specificity	Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary.
Posttranslational modification	Monoubiquitinated by NEDD4. Polyubiquitinated, leading to its degradation by the proteasome. Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation. Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (By similarity).
Celluar localization	Nucleus;
UniPort	O75113