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Rabbit Anti-N Myc Polyclonal Antibody#abs131298

Rabbit Anti-N Myc Polyclonal Antibody#abs131298

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Description

Catalog-specification

Delivery time

USD price

abs131298-50ug

1-2 Weeks

201

abs131298-100ug

1-2 Weeks

301

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to contact our seller Vecent. It is important to note that the price may vary based on additional factors which will be communicated by our representative. Thank you for choosing us as your preferred provider.


Overview

Description

The amplification of the N-MYC gene has been linked to several human tumors, with neuroblastoma being the most commonly affected cancer. As the tumor progresses, the degree of amplification seems to steadily rise, indicating a close association between this gene and cancer development.
Other namesClass E basic helix-loop-helix protein 37, also known as bHLHe37, is a protein encoded by the NMYC gene. This gene is known to play a critical role in the development of the nervous system, and its dysfunction has been linked to various types of cancer, particularly neuroblastoma. The NMYC gene encodes the N-myc proto-oncogene protein, which is a member of the Myc family of transcription factors. This protein acts as a regulator of cell growth and differentiation, and its overexpression is associated with aggressive tumor growth and poor prognosis.
Other aliases for the NMYC gene include Mycn, N myc, ODED, pp65/67, and V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog. The v-myc avian myelocytomatosis viral related oncogene is the avian counterpart of the NMYC gene in humans. The NMYC proto-oncogene protein is a transcription factor that regulates the expression of genes involved in DNA replication, cell cycle progression, and apoptosis. It is also involved in the regulation of telomerase activity, which plays a critical role in cancer development and progression.
The N-myc proto-oncogene protein is often overexpressed in neuroblastoma, a type of cancer that arises in the nervous system. This overexpression is thought to contribute to tumor growth and metastasis, as well as resistance to chemotherapy and radiation therapy. Targeting the NMYC gene has been identified as a potential therapeutic strategy for the treatment of neuroblastoma and other types of cancer that overexpress N-myc.
SourceRabbit
SpecificityThe endogenous levels of total N Myc can be detected using N Myc Antibody.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesPig;Sheep;Bovine
AntigenN Myc
ApplicationThe dilutions for the Western blot (WB) assay range from 1:500 to 1:2000. For the immunohistochemistry (IHC) assay, the dilutions are between 1:50 and 1:200. When it comes to the ELISA assay using a peptide, the recommended dilutions are 1:20,000 to 1:40,000. Additionally, for the second ELISA assay also using a peptide, the dilution range remains the same at 1:20,000 to 1:40,000. It is essential to follow these dilution guidelines for optimal results in these assays.
ImmunogenA synthesized peptide derived from human N Myc.
MW49 kDa
Properties

Concentration

1mg/ml
purificationThe SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. This process resulted in a highly purified final product with a high degree of similarity to the original substance.
ClonalityPolyclonal Antibody
Stability & StoragePlease ensure that the product is stored at a temperature of -20 °C for a duration of one year without being subject to repeated freeze/thaw cycles.
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Tissue specificityExpressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
Posttranslational modificationPhosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509). Phosphorylated by AURKA (PubMed:27837025).
Celluar localizationNucleus;
UniPortP04198



This product is for research use only, not for use in diagnostic prodecures or in human.

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