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Rabbit Anti-MyD88 Polyclonal Antibody#abs131286

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Description

Catalog-specification	Delivery time	USD price
abs131286-100ug	In Stock	301.0
abs131286-50ug	In Stock	201.0

Overview
catalog	abs131286
Description	The Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response involves an adapter protein. This adapter protein acts through IRAK1, IRAK2, IRF7, and TRAF6 to initiate NF-kappa-B activation, cytokine secretion, and the inflammatory response. Additionally, it enhances IL-8 transcription and participates in the IL-18-mediated signaling pathway.
Other names	Myeloid differentiation primary response 88, also known as MYD88 or Myd88, is a crucial protein involved in myeloid cell differentiation. It serves as a marker for myeloid differentiation and is encoded by the MYD88 gene. MYD88 plays a significant role in initiating immune responses through various signaling pathways. MYD88 is known for its involvement in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. Upon activation of these receptors, MYD88 recruits downstream signaling molecules and forms a complex that activates nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs). This activation leads to the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), promoting immune responses against pathogens. Several diseases and disorders have been linked to MYD88 dysregulation. Mutations in MYD88 have been associated with certain types of lymphoma, including Waldenstrom macroglobulinemia and activated B-cell-like diffuse large B-cell lymphoma. These mutations result in constitutive activation of the NF-κB pathway, contributing to the development and progression of these lymphomas. Understanding the functions and regulation of MYD88 is crucial for developing targeted therapies for various diseases. Further research into MYD88 and its interaction with other signaling molecules will provide valuable insights into the intricate mechanisms underlying immune responses and diseases involving myeloid differentiation.
Source	Rabbit
Specificity	The detection of total MyD88 is accomplished by the MyD88 Antibody, which specifically recognizes the endogenous levels of MyD88 protein. To emphasize, this antibody targets the overall expression of MyD88 within the biological system.
Species Reactivity	Human;Mouse;Rat;Monkey
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	MyD88
Application	The recommended dilutions for WB are 1:500-1:2000, for IHC are 1:50-1:200, for IF/ICC are 1:100-1:500, and for ELISA (peptide) are 1:20000-1:40000. It is important to follow these dilution guidelines to ensure accurate results in your experiments.
Immunogen	A synthesized peptide derived from human MyD88.
MW	33 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Tissue specificity	Ubiquitous.
Celluar localization	Cytosol;Endosome;Nucleus;Plasma Membrane;
UniPort	Q99836