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Rabbit Anti-MAP2K5 Polyclonal Antibody#abs137144

Description

Catalog-specification	Delivery time	USD price
abs137144-100ug	1-2 Weeks	301.0
abs137144-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137144
Other names	MAP kinase kinase 5, also known as dual specificity mitogen-activated protein kinase kinase 5 or MEK 5, is an enzyme encoded by the gene HsT17454. It belongs to the family of mitogen-activated protein kinases (MAPKs) and plays a crucial role in cellular signaling pathways. MEK 5 is an EC 2.7.12.2 enzyme that phosphorylates and activates specific MAPKs, such as ERK, leading to the regulation of various cellular processes. The physiological functions of MEK 5 are diverse and dynamic. Its activation can be triggered by various extracellular signals, including growth factors, cytokines, and stress factors. Once activated, MEK 5 phosphorylates specific residues on its downstream targets, thereby activating them and initiating a cascade of signaling events. This signaling cascade ultimately regulates processes such as cell proliferation, differentiation, survival, and apoptosis. MEK 5 has been implicated in numerous biological processes and diseases. Dysregulation of its activity has been associated with the development and progression of cancers, neurological disorders, and cardiovascular diseases. Therefore, MEK 5 has emerged as a potential therapeutic target for these diseases. In summary, MEK 5, also known as MAP kinase kinase 5, is a crucial player in cellular signaling pathways. Its activation and subsequent phosphorylation of specific MAPKs regulate various cellular processes. Further research on MEK 5's role in disease pathology may provide new insights and therapeutic opportunities.
Source	Rabbit
Specificity	The MAP2K5 Antibody is capable of detecting the total amount of endogenous MAP2K5 present in a given sample. This indicates that the antibody can identify the entire quantity of MAP2K5 that occurs naturally in the sample.
Species Reactivity	Human
Antigen	MAP2K5
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MAP2K5.
MW	50kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure its quality and effectiveness, only the most pure and refined version of the antiserum was chosen. Through this process, all other contaminants and unwanted substances were removed, resulting in a highly concentrated and potent antiserum. This meticulous process guarantees that the antiserum is of the utmost quality and able to effectively combat the targeted antigen.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple cycles of freezing and thawing. Taking necessary precautions will ensure the long-term storage of the product without compromising its integrity.
Storage buffer	The Rabbit IgG solution is formulated in a phosphate buffered saline at pH 7.4, supplemented with 150mM NaCl, 0.02% of sodium azide, and 50% glycerol. It is advised to store the solution at a temperature of -20°C. For a period of 12 months, the solution remains stable from the date of its receipt. The composition and storage conditions of the Rabbit IgG solution make it ideal for laboratory use. It is important to handle it with care to ensure optimum performance.
Target
Background	Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Tissue specificity	Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Posttranslational modification	Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q13163