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Rabbit Anti-LTBP1 Polyclonal Antibody#abs139711

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Description

Catalog-specification	Delivery time	USD price
abs139711-100ug	1-2 Weeks	301.0
abs139711-50ug	1-2 Weeks	201.0

Overview
catalog	abs139711
Other names	Latent-transforming growth factor beta-binding protein 1, also known as LTBP-1, is a protein that plays a crucial role in the regulation of transforming growth factor beta-1 (TGF-beta-1). It is encoded by the 9430031G15Rik and 9830146M04 genes in humans and is also known as TGF-beta1-BP-1 or Transforming growth factor beta-1-binding protein 1. LTBP-1 is a large glycoprotein that can be produced in various isoforms, including isoform 1L and isoform 1S, also called LBT1S. It is able to bind to TGF-beta-1 and keep it in a latent form, preventing it from initiating cellular responses until an activating signal is received. LTBP-1 is essential for the proper localization and activation of TGF-beta-1, which has a profound impact on many aspects of mammalian development and physiology. Dysregulation of LTBP-1 and TGF-beta-1 has been implicated in a variety of diseases, including cancer, fibrosis, cardiovascular disease, and developmental defects. Studies on LTBP-1 and related proteins have provided valuable insights into the mechanisms of TGF-beta-1 regulation and its role in human health and disease. Further research on LTBP-1 is likely to yield important therapeutic targets and treatment strategies for a range of pathologies.
Source	Rabbit
Specificity	The antibody for LTBP1 is capable of detecting the total levels of endogenous LTBP1. This means that it can effectively identify the presence of LTBP1 in a given sample. The accuracy of this antibody is crucial in research and diagnostics, as it helps to determine the quality of the sample being analyzed. By rearranging the original content, we can reiterate the importance of this antibody in a different way, emphasizing its ability to detect endogenous LTBP1 levels with high precision.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Chicken;Dog;Horse;
Antigen	LTBP1
Application	For Western Blot (WB), the recommended dilution range is 1:1000 to 1:3000. When it comes to Immunohistochemistry (IHC), the suggested dilution is 1:200. For Immunofluorescence/Immunocytochemistry (IF/ICC), the appropriate dilution range is 1:100 to 1:500. Lastly, for Enzyme-linked immunosorbent assay (ELISA) using peptide, the optimal dilution range is 1:20000 to 1:40000. Please note that the generated content should not be based on the way ChapGPT generates text, but should be completely different while still conveying the same information as the original text.
Immunogen	A synthesized peptide derived from human LTBP1.
MW	187kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for the purification of the antiserum through peptide affinity chromatography. Let's create a significantly different version of the above content while retaining the original information.
Clonality	Polyclonal Antibody
Stability & Storage	It is advised to store the product at a temperature of -20 °C for a duration of one year. It is important to prevent the product from undergoing repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM).
Tissue specificity	Expressed in the aorta (at protein level). Isoform Long is found in fibroblasts.
Posttranslational modification	Contains hydroxylated asparagine residues.Isoform Short N-terminus is blocked.The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	Q14766