Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-LTA4H Polyclonal Antibody#abs136491

Description

Catalog-specification	Delivery time	USD price
abs136491-100ug	1-2 Weeks	301.0
abs136491-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for reference purposes, and for detailed pricing, we kindly request you to get in touch with our sales representative, Vecent. We would like to emphasize that the information shared is based on the original text, but we request you to refrain from using any conversational text generated by ChapGPT and kindly rephrase the content in a language model-generated text, which is significantly different from the original text.

Overview
catalog	abs136491
Other names	Leukotriene A(4) hydrolase, also known as LTA-4 hydrolase and LTA4H, is an important enzyme that plays a crucial role in the biosynthesis of leukotrienes. LTA4H is responsible for the hydrolysis of leukotriene A4 (LTA4), a key intermediate in the synthesis of leukotriene B4 (LTB4) and cysteinyl leukotrienes (LTC4, LTD4, and LTE4). This enzyme is encoded by the FLJ17564 gene in humans. Leukotrienes are potent bioactive lipids that are involved in a variety of physiological processes, such as inflammation, immune response, and smooth muscle contraction. Dysregulation of leukotriene biosynthesis and signaling has been linked to various diseases, including asthma, allergic rhinitis, and cardiovascular disorders. LTA4H is widely expressed in various tissues, including the lungs, spleen, liver, and kidney. It is a zinc metalloprotease that belongs to the M1 family of aminopeptidases. The enzyme has a molecular weight of approximately 75 kDa and consists of two subunits, an alpha subunit and a beta subunit. LTA4H has been extensively studied as a potential therapeutic target for diseases associated with leukotriene dysregulation. Inhibitors of LTA4H have been developed as potential drugs for the treatment of asthma, chronic obstructive pulmonary disease (COPD), and other inflammatory disorders. In conclusion, LTA4H is a crucial enzyme in the biosynthesis of leukotrienes, and dysregulation of its activity is implicated in various disease states. Much research is currently being conducted to develop new drugs targeting this enzyme for therapeutic purposes.
Source	Rabbit
Specificity	The LTA4H Antibody is capable of recognizing the total levels of endogenous LTA4H protein. To rephrase this information, one can say that the antibody has the ability to detect the complete amount of LTA4H protein present within the organism.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Horse;
Antigen	LTA4H
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB has a dilution range of 1:500-1:2000, IHC has a dilution range of 1:50-1:200, and ELISA (peptide) has a dilution range of 1:20000-1:40000. It is important to ensure accurate dilution ratios when performing these assays to obtain reliable results.
Immunogen	A synthesized peptide derived from human LTA4H.
MW	69kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. An exhaustive purification process was performed to ensure the highest quality of the final product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to keep it stored at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated thaw and freeze cycles as this can affect its properties. Ensuring proper storage conditions is essential for maintaining the integrity of the product.
Storage buffer	This product contains Rabbit IgG in a buffered saline solution with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability, store the solution at a temperature of -20 °C. It is recommended to use the product within 12 months from the date of receipt.
Target
Background	Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
Tissue specificity	Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
Posttranslational modification	Phosphorylation at Ser-416 inhibits enzymatic activity.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P09960