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Phospho-MKP-7 (Ser446) Rabbit Polyclonal Antibody#abs140116

Description

Catalog-specification	Delivery time	USD price
abs140116-100ug	1-2 Weeks	301.0
abs140116-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140116
Other names	One of the proteins that play a crucial role in cell signaling pathways is dual specificity phosphatase 16, also known as DUSP16. This protein is encoded by the KIAA1700 gene and functions as a dual specificity protein phosphatase, which means it can dephosphorylate both tyrosine and serine/threonine residues on target proteins. Another name for DUSP16 is mitogen-activated protein kinase phosphatase 7, or MAPK phosphatase 7. DUSP16 is involved in various cellular processes, such as cell growth and differentiation, apoptosis, and inflammation. It can regulate the activity of several signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway. By dephosphorylating MAPKs, such as ERK, JNK, and p38, DUSP16 can modulate their downstream targets and affect cell behavior. In addition to its role in normal cellular physiology, DUSP16 is also implicated in several diseases. For instance, it has been shown to play a role in the development of certain cancers, such as breast and lung cancer, by regulating cell proliferation and survival. Therefore, DUSP16 has emerged as a potential therapeutic target for cancer treatment. In summary, DUSP16 is a dual specificity protein phosphatase that has diverse functions in cell signaling pathways. It regulates the activity of MAPKs and influences various cellular processes. Moreover, its involvement in disease pathogenesis makes it an attractive target for therapeutic intervention.
Source	Rabbit
Specificity	The MKP-7 (Phospho-Ser446) Antibody is designed to specifically detect the phosphorylation of MKP-7 at Ser446. It can accurately target only the endogenous levels of MKP-7 protein that have undergone this specific phosphorylation event. This provides researchers with a reliable tool for investigating the function and activity of MKP-7 in various biological processes. The antibody's high specificity and sensitivity make it suitable for a range of applications, including western blot, immunohistochemistry, and immunofluorescence assays, among others. Overall, the MKP-7 (Phospho-Ser446) Antibody is an essential tool for investigating the role of MKP-7 in cellular signaling pathways and molecular mechanisms.
Species Reactivity	Human;Mouse
Antigen	MKP-7
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	MKP-7（446）。。，。ChapGPT，。
MW	73kDa
Properties
Concentration	1mg/ml
purification	The procedure used to obtain the antibody involved purification of rabbit serum through sequential chromatography on columns that were specific to phospho- and non-phospho-peptides. This process entails affinity purification to isolate and concentrate the antibodies for subsequent analyses or uses.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the storage temperature remains at -20 °C for a period of one year and refrain from exposing the product to fluctuating freeze/thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is in a solution containing phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C. It is stable for a period of 12 months from the date of receipt.
Target
Background	Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Posttranslational modification	Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.(Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9BY84