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Rabbit Anti-TrpRS Polyclonal Antibody#abs132859

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Description

Catalog-specification	Delivery time	USD price
abs132859-100ug	1-2 Weeks	301.0
abs132859-50ug	1-2 Weeks	201.0

Overview
catalog	abs132859
Other names	Mitochondrial tryptophanyl tRNA synthetase 2, also known as TrpRS or Tryptophan tRNA ligase 2, is a crucial enzyme involved in protein synthesis. The enzyme belongs to the aminoacyl-tRNA synthetase family and is responsible for attaching tryptophan to its corresponding tRNA molecule during protein translation. Tryptophan tRNA ligase 2 mitochondrial, as it is sometimes called, is found exclusively in the mitochondria of eukaryotic cells. It plays an essential role in maintaining the correct sequence of amino acids during protein synthesis, ensuring the proper folding and function of new proteins. The Tryptophanyl tRNA synthetase 2 mitochondrial gene is located on chromosome 6 in humans and has been shown to be highly conserved among different species. Mutations in this gene have been linked to various types of developmental disorders and neurological diseases. Overall, the precise functioning of (Mt)TrpRS is critical to the proper functioning of cells and organismal health. Its complex biochemical mechanisms continue to be an area of active research and discovery.
Source	Rabbit
Specificity	The endogenous levels of total TrpRS can be accurately detected using the TrpRS antibody. Let me rearrange the content in a highly similar manner: "The TrpRS antibody is an effective tool for detecting the total TrpRS levels present within the organism. It allows for the precise measurement of endogenous TrpRS protein levels."
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	TrpRS
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	23 kDa
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was achieved through the utilization of SulfoLink™ Coupling Resin in a peptide affinity chromatography process.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store the product at -20 °C for a duration of one year, without subjecting it to repeated freeze/thaw cycles.
Storage buffer	This solution contains Rabbit IgG suspended in a buffer of phosphate and saline, with a pH of 7.4. Additionally, the solution contains 150 millimoles of NaCl, as well as a small amount of sodium azide at 0.02%. Finally, the solution is stabilized with a 50% concentration of glycerol.
Target
Background	ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).
Tissue specificity	Brain.
Celluar localization	Mitochondrion;Plasma Membrane;
UniPort	Q9UGM6