Rabbit Anti-LDLR Polyclonal Antibody#abs137173
Please note that the price mentioned above is only for reference purposes. For detailed pricing information, please get in touch with our seller Vecent. It is important to clarify that the final cost may vary based on various factors and therefore it is essential to speak with a sales...
Description
| Catalog-specification | Delivery time | USD price |
abs137173-100ug | 1-2 Weeks | 301.0 |
abs137173-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for reference purposes. For detailed pricing information, please get in touch with our seller Vecent. It is important to clarify that the final cost may vary based on various factors and therefore it is essential to speak with a sales representative to get accurate information. So, please don't hesitate to contact us for further details.
| Overview | |
catalog | abs137173 |
| Other names | The LDL receptor, also known as the low-density lipoprotein receptor, or LDLCQ2, plays a critical role in regulating cholesterol levels in the body. Mutations in the LDLR gene can lead to familial hypercholesterolemia, a condition characterized by high levels of LDL (the "bad" cholesterol) in the blood. The LDL R protein contains a class A domain and is encoded by the Ldlr gene in humans. Additionally, another protein known as low density lipoprotein receptor class A domain containing protein 3 (LDLRAP3) is involved in LDL receptor-mediated endocytosis. Understanding the function of these proteins is essential for developing interventions to prevent and treat hypercholesterolemia and other related conditions. |
| Source | Rabbit |
| Specificity | The LDLR Antibody has the ability to detect the complete amount of endogenous LDLR present in the system. This means that the antibody can recognize and bind to LDLR proteins that are naturally produced within the body. By detecting the total amount of LDLR, researchers can gain insights into the functions and roles of this important protein. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Horse; |
| Antigen | LDLR |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthesized peptide derived from human LDLR. |
| MW | 140 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | We employed SulfoLink™ Coupling Resin in peptide affinity chromatography to purify the antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain optimal storage conditions, it is recommended to store the item at a temperature of -20°C for a period of one year. It is advisable to avoid any repeated freeze/thaw cycles as this may affect the quality of the item. Take necessary precautions and handle with care to ensure the item is stored in the appropriate manner. |
| Storage buffer | The storage conditions for Rabbit IgG include keeping it in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. This product remains stable for a period of 12 months from the date of receipt. |
Target | |
Background | Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. |
| Posttranslational modification | N- and O-glycosylated.Ubiquitinated by MYLIP leading to degradation. |
| Celluar localization | Endosome;Extracellular region or secreted;Golgi apparatus;Lysosome;Plasma Membrane; |
| UniPort | P01130 |
Western blot analysis LDLR using HeLa whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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