Rabbit Anti-KISS1 Polyclonal Antibody#abs136653

abs136653-100ug

In Stock

301.0

abs136653-50ug

In Stock

201.0

catalog

Description

This particular gene is known as a metastasis suppressor gene which has the ability to suppress the spread of melanomas and breast carcinomas, while not affecting their ability to form tumors. The protein produced by this gene may hinder the movement and invasion of cells, thus reducing the likelihood of metastasis in malignant melanomas. Research suggests that this gene may also play a role in regulating processes that occur after cells adhere to the extracellular matrix, potentially involving reorganization of the cytoskeleton. Additionally, one of the protein products of this gene, called kisspeptin, stimulates the release of gonadotropin-releasing hormone (GnRH) which, in turn, controls the secretion of gonadotropins and plays a role in triggering puberty by activating GnRH neurons. Notably, a variation in the terminal section of this gene's mRNA can lead to the production of two different protein isoforms. Specifically, the presence or absence of an adenosine at a specific site alters the reading frame, resulting in the utilization of a different stop codon and the extension of the encoded protein by an additional seven amino acid residues.

Concentration

1mg/ml

Target

Background

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.