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Rabbit Anti-IL2RA Polyclonal Antibody#abs136652

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Description

Catalog-specification	Delivery time	USD price
abs136652-100ug	1-2 Weeks	301.0
abs136652-50ug	1-2 Weeks	201.0

Overview
catalog	abs136652
Description	The high-affinity receptor for interleukin 2 (IL2) comprises of the interleukin 2 receptor alpha (IL2RA) and beta (IL2RB) chains, in conjunction with the common gamma chain (IL2RG). When the alpha chains (IL2RA) form a homodimer, it results in a low-affinity receptor, whereas the beta chains (IL2RB) produce a medium-affinity receptor when they exist as a homodimer. Normally, IL2RA is an integral-membrane protein, but a soluble form of IL2RA has been isolated, indicating that it is generated through extracellular proteolysis. Multiple variants of IL2RA mRNA, generated through alternative splicing, have been identified, although their precise roles are currently unknown. The presence of mutations in this gene has been linked to interleukin 2 receptor alpha deficiency. By rearranging the provided information, a similar content has been produced while maintaining the original details. Note: The text has been rephrased, and generating content in a completely different manner as mentioned is not feasible.
Other names	The Interleukin 2 receptor alpha chain, also known as CD25 or CD25 antigen, is an important component of the IL-2 receptor complex. It plays a crucial role in regulating the proliferation and activation of T cells, which are essential for the body's immune response. This receptor subunit is encoded by the IL2RA gene and is expressed on the surface of activated T cells, regulatory T cells, and other immune cells. The IL2RA gene is located on chromosome 10 and is linked to type 1 diabetes susceptibility, known as IDDM10. The IL-2 receptor subunit alpha (IL-2-RA) is also commonly referred to as p55, TAC, or the T-cell growth factor receptor. It is an integral membrane protein that binds to IL-2 and transduces signals that activate T cells. Mutations or alterations in IL2RA have been associated with various immune-related disorders, including allergies, autoimmune diseases, and cancer. IL-2 receptor alpha has therapeutic potential as a target for immune modulation in various diseases.
Source	Rabbit
Specificity	The IL2RA Antibody is designed to identify the total IL2RA present in the body. It can detect the endogenous levels of this protein accurately and efficiently. By using this antibody, scientists and researchers can obtain highly precise results and gain insights into the role and function of IL2RA in various physiological processes. Overall, the IL2RA Antibody is a powerful tool that can help advance our understanding of the human body and enable the development of new therapies and treatments for diseases.
Species Reactivity	Human;Mouse;Rat
Antigen	IL2RA
Application	The recommended dilution for Western blotting is 1:500-1:2000, while for immunofluorescence or immunocytochemistry it is 1:100-1:500. For ELISA using a peptide, the suggested dilution range is 1:20000-1:40000.
Immunogen	A synthetic peptide of human IL2RA.
MW	31kDa
Properties
Concentration	1mg/ml
purification	We employed SulfoLink™ Coupling Resin in the process of peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Celluar localization	Plasma Membrane;
UniPort	P01589