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Rabbit Anti-THBD Polyclonal Antibody#abs134867

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Description

Catalog-specification	Delivery time	USD price
abs134867-100ug	1-2 Weeks	301.0
abs134867-50ug	1-2 Weeks	201.0

Overview
catalog	abs134867
Other names	AHUS 6, also known as AHUS6, is a rare genetic disorder characterized by abnormal activation of the complement system, leading to damage to various organs. BDCA 3, or BDCA3, is a dendritic cell subset marker that plays a crucial role in the immune response. Another antigen, CD141 or CD141 antigen, is a specific protein marker found on certain immune cells. Fetomodulin, also referred to as Thbd, THPH12, or THRM, is a cell surface protein involved in embryonic development and tissue remodeling. Thrombomodulin, commonly known as TM or TRBM_HUMAN, is a glycoprotein that regulates blood coagulation and inflammation. These proteins have different functions but are related to various aspects of immune response and tissue regulation.
Source	Rabbit
Specificity	Our highly sensitive THBD Antibody is capable of detecting the levels of endogenous total THBD in any given sample. The antibody provides accurate results and can be used in various applications.
Species Reactivity	Human;Mouse;Rat
Antigen	THBD
Application	The recommended dilutions for Western blotting are in the range of 1:500 to 1:1000, while for immunofluorescence/immunocytochemistry, it is advisable to use dilutions ranging from 1:100 to 1:500. For ELISA with peptides, a dilution of 1:20000 to 1:40000 is recommended. Please note that these dilutions are crucial for ensuring accurate and reliable results in molecular biology experiments.
Immunogen	A synthesized peptide.
MW	60 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to isolate and purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, it is recommended to store it at a temperature of -20 °C for one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	This antibody product contains Rabbit IgG in a solution of phosphate buffered saline at pH 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to be stored at a temperature of -20 °C, and has a shelf life of 12 months from the date of receipt. This product is ideal for use in various immunological applications, such as western blotting, immunofluorescence, and immunohistochemistry. It is a reliable and high-quality solution for researchers and scientists in the field of antibody research.
Target
Background	Thrombomodulin is a receptor found specifically in endothelial cells that binds to thrombin in a 1:1 ratio. The complex formed by this binding is responsible for converting protein C to activated protein C (protein Ca). Once activated, protein Ca breaks down the active cofactors of the coagulation cascade, factors Va and VIIIa, which results in the reduction of thrombin production. By rearranging the information presented in the original text, we can see that thrombomodulin functions as a key regulator in the coagulation process, and its interaction with thrombin plays a crucial role in controlling the amount of thrombin generated. The activation of protein C by thrombomodulin furthermore contributes to the maintenance of hemostasis by preventing excessive clotting.
Tissue specificity	Endothelial cells are unique in synthesizing thrombomodulin.
Posttranslational modification	N-glycosylated.The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P07204