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Rabbit Anti-KHDRBS1 Polyclonal Antibody#abs137330

Description

Catalog-specification	Delivery time	USD price
abs137330-100ug	1-2 Weeks	301.0
abs137330-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.
Kindly note that the price mentioned above is for reference purposes only. For detailed information on pricing, we recommend contacting our seller, Vecent.
Please be advised that the price stated above is provided for your reference only. To obtain detailed pricing information, please reach out to our seller, Vecent.
It is important to note that the price mentioned above is solely for your reference. For a comprehensive understanding of the pricing details, we recommend contacting our seller, Vecent.

Overview
catalog	abs137330
Other names	The protein known as p62 is also referred to as GAP associated tyrosine phosphoprotein p62, or KH domain containing RNA binding signal transduction associated 1. It's also sometimes called Src associated in mitosis 68 kDa protein, or signal transduction-associated protein 1. Another name for this protein is Sam68, which stands for Src-associated in mitosis 68 kDa protein. p62 is a RNA-binding protein that contains a KH domain, which is responsible for its RNA binding ability. This protein is known to be involved in signal transduction pathways and is important in regulating cell growth and survival. p62 has also been linked to the regulation of Ras GTPase activity. Specifically, it is thought to play a role in the regulation of p21 Ras GTPase, which is an important mediator of cell growth and differentiation. Overall, p62 is a versatile protein that plays important roles in many cellular processes, including signal transduction, RNA binding, and the regulation of cell growth and survival. Its multiple names reflect its different functions and the variety of cellular pathways it is involved in.
Source	Rabbit
Specificity	The KHDRBS1 Antibody is designed to recognize total KHDRBS1 levels in the body. It is able to detect endogenous amounts of this protein. To create a similar content, I rearrange the original description while keeping its meaning intact.
Species Reactivity	Human;Mouse
Antigen	KHDRBS1
Application	Here are some new ways to present the same information as the original text: - For Western blot analysis, a dilution of 1:1000-3000 is recommended, while a dilution of 1:200 is optimal for immunohistochemistry. In ELISA using peptide antigens, a dilution range of 1:20000-1:40000 is suggested. - The recommended dilution range for Western blotting is 1:1000-3000, while for immunohistochemistry, a dilution of 1:200 is preferred. When using peptide antigens in ELISA, a dilution range of 1:20000-1:40000 is appropriate. - Different dilutions are recommended for different applications of these antibodies. Western blotting should use a dilution of 1:1000-3000, while immunohistochemistry requires a lower dilution of 1:200. For ELISA experiments with peptide antigens, a dilution range of 1:20000-1:40000 is best. - To achieve optimal results in Western blot analysis, a dilution of 1:1000-3000 is recommended, whereas immunohistochemistry works best with a dilution of 1:200. When using peptide antigens in ELISA, it is suggested to use a dilution range of 1:20000-1:40000. - Depending on the experimental setup, the recommended dilution for these antibodies vary. Western blotting should use a dilution of 1:1000-3000, while immunohistochemistry requires a lower dilution of 1:200. For ELISA experiments using peptide antigens, a dilution range of 1:20000-1:40000 is suggested.
Immunogen	A synthesized peptide derived from human KHDRBS1.
MW	48 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of your product, it is recommended that you store it at a temperature of -20 °C for up to one year. It is important to note that repeated freeze/thaw cycles should be avoided, in order to prevent any potential damage or degradation to the product. By following these storage guidelines, you can ensure that your product remains stable and effective throughout its shelf life.
Storage buffer	This product is Rabbit IgG in a solution containing phosphate buffered saline with a pH of 7.4, 150mM sodium chloride, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20°C for optimal stability, and has a shelf life of 12 months from the date it was received. Please be sure to maintain these storage conditions in order to ensure the quality of the product remains intact.
Target
Background	Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).
Tissue specificity	Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
Posttranslational modification	Tyrosine phosphorylated by several non-receptor tyrosine kinases, LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins. Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nulear localization of KHDRBS1. Phosphorylation at Tyr-387 disrupts interaction with APC. Phosphorylation at tyrosine residues by FYN inverts activity on modulation of BCL2L1 alternative splicing.Acetylated. Positively correlates with ability to bind RNA.Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30.
Celluar localization	Cytosol;Nucleus;Plasma Membrane;
UniPort	Q07666