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Rabbit Anti-JDP2 Polyclonal Antibody#abs139607

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Description

Catalog-specification	Delivery time	USD price
abs139607-100ug	1-2 Weeks	301.0
abs139607-50ug	1-2 Weeks	201.0

Overview
catalog	abs139607
Other names	JDP2, also known as Jun dimerization protein 2 or JUNDM2, is a progesterone receptor co-activator that plays an important role in regulating gene expression. This protein is highly similar to JDP1 and belongs to the bZIP family of transcription factors. JDP2 forms bioactive dimers with other bZIP proteins, such as FOS and ATF2, and binds to specific DNA sequences to modulate transcriptional activity. Additionally, JDP2 has been implicated in various cellular processes, including cell differentiation, apoptosis, and tumorigenesis. Understanding the function of JDP2 is crucial for advancing our knowledge of gene regulation and developing potential therapeutic strategies.
Source	Rabbit
Specificity	The JDP2 Antibody has the ability to identify the total amount of endogenous JDP2 present in the sample. This information is useful in determining the level of JDP2 in a biological sample and its potential role in different cellular processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	JDP2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human JDP2.
MW	19 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. To ensure high levels of similarity between the generated content and the original text information, the wording and order of information were altered while retaining the same meaning.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the product stored at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing. This will help ensure the stability and integrity of the product over time.
Storage buffer	The storage condition for Rabbit IgG is -20 °C in phosphate buffered saline with a pH of 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that this product is stable for a period of 12 months starting from the date of receipt.
Target
Background	Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Posttranslational modification	Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.Polyubiquitinated; probably by IRF2BP1.
Celluar localization	Nucleus;
UniPort	Q8WYK2