Rabbit Anti-GluR5 Polyclonal Antibody #abs130106

abs130106-50ug

1-2 Weeks

201

abs130106-100ug

1-2 Weeks

301

Description

The GluR5 ionotropic glutamate receptor is responsible for the transmission of crucial signals in the central nervous system. L-glutamate, an excitatory neurotransmitter, plays a vital role in this process by binding to the receptor and inducing a conformational change, culminating in the opening of a cation channel. This channel, in turn, converts the chemical signal to an electrical impulse, thereby facilitating the transmission of information. However, the receptor has a rapid desensitization process, entering a transient inactive state as a result. During this time, the receptor remains unresponsive despite the presence of bound agonists. Interestingly, the receptor may also participate in the transmission of light information from the retina to the hypothalamus.

Other names

GLR5, also known as EAA3 or EEA3, is an excitatory amino acid receptor that plays a crucial role in mediating synaptic transmission. It is encoded by the GRIK1 gene in humans. GLR5 belongs to the ionotropic glutamate receptor family, specifically the kainate subtype.
The human glutamate receptor GLUR5 is closely related to other members of the family, such as GluR-5, GluR6, and GluR7. These receptors are responsible for the transmission of signals in the central nervous system, particularly in areas involved in learning, memory, and neuronal plasticity.
GRIK1_HUMAN is the official gene symbol for the human glutamate receptor ionotropic kainate 1. It serves as an identifier for this particular receptor in scientific research.
OTTHUMP00000096569 is another identifier used to represent GLR5 in genetic databases. This identifier helps researchers to locate and study the gene associated with this receptor.
In summary, GLR5, or EAA3, is an important receptor involved in synaptic transmission and belongs to the ionotropic glutamate receptor family. It is closely related to other glutamate receptor subtypes, such as GluR-5, GluR6, and GluR7. The GRIK1 gene encodes the human glutamate receptor GLUR5, and OTTHUMP00000096569 is an identifier associated with this receptor.

Source

Rabbit

Specificity

The GluR5 antibody is capable of detecting the overall levels of endogenous GluR5. This means that it can accurately identify the total amount of GluR5 present in a sample.

Species Reactivity

Human;Mouse;Rat

Predictive reaction species

Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine

Application

The dilution ratio for Western blotting ranges from 1:500 to 1:3000, while for immunohistochemistry it is recommended to dilute at 1:50 to 1:200. For ELISA using peptide antigens, the optimal dilution range is between 1:20000 and 1:40000. It is important to carefully follow these dilution guidelines to obtain accurate and reliable results in your experiments. Be sure to use high-quality antibodies and reagents to ensure optimal performance and reproducibility.

Immunogen

A synthesized peptide derived from human GluR5.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography for its purification.

Clonality

Polyclonal Antibody

Stability & Storage

To ensure the longevity and effectiveness of this product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can compromise its quality. Follow these guidelines carefully to maintain the potency of the product over an extended period of time.

Storage buffer

This product is Rabbit IgG dissolved in phosphate buffered saline, with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C. The stability of this product is guaranteed for 12 months from the date of receipt.

Target

Background

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Tissue specificity

Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.

Celluar localization

Plasma Membrane;

UniPort

P39086