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Rabbit Anti-ITGB7 Polyclonal Antibody#abs132923

Please be advised that the price provided is for your reference. For specific pricing details, please contact our sales representative Vecent. Western blot analysis of ITGB7 expression in A431 whole cell lysate ,The lane on the left is treated with the antigen-specific peptide. This product is...

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Description

Catalog-specification	Delivery time	USD price
abs132923-50ug	1-2 Weeks	201.0
abs132923-100ug	1-2 Weeks	301.0

Please be advised that the price provided is for your reference. For specific pricing details, please contact our sales representative Vecent.

Overview
catalog	abs132923
Description	The integrin alpha-4/beta-7 molecule is an essential component for facilitating lymphocyte migration and homing to the gut. This molecule interacts with various adhesion molecules such as MADCAM1, VCAM1, and fibronectin found on the surface of the endothelium and extracellular matrix components of the gastrointestinal tract. The alternatively spliced CS-1 region of fibronectin recognizes one or more domains within this molecule. Interestingly, HIV-1 gp120 also binds to integrin alpha-4/beta-7, allowing the virus to enter GALT and potentially triggering AIDS disease. This interaction involves a tripeptide L-D-I in the virus's gp120. Another receptor for E-cadherin is integrin alpha-E/beta-7 (HML-1).
Other names	Receptor beta subunit, gut homing; subunit beta-7 integrin; beta-7 integrin; beta-P integrin; integrin, beta 7; ITB7; ITB7_HUMAN; Itgb7; Ly69; M290 IEL antigen. Generate a highly similar content by rearranging the above information: Integrin beta-7, also known as ITB7, is a receptor composed of a beta subunit that plays a crucial role in gut homing. It is involved in cell adhesion and migration within the gut mucosa. The ITB7 protein, encoded by the Itgb7 gene, is also referred to as beta-P integrin or M290 IEL antigen. Additionally, Ly69 is another name for Integrin beta-7, emphasizing its association with lymphocyte function.
Source	Rabbit
Specificity	The levels of total ITGB7 can be detected using the ITGB7 antibody, allowing for the assessment of endogenous expression.
Species Reactivity	Human
Predictive reaction species	Sheep;Dog;Horse
Antigen	ITGB7
Application	The recommended dilution range for this antibody is WB 1:500-1:2000, IHC 1:50-1:200, and ELISA (peptide) 1:20000-1:40000. It is important to use the appropriate dilution in order to achieve accurate and reliable results in your experiments. Working within these dilution ranges can help ensure that your data is both informative and reproducible. So, be sure to carefully consider your experimental design and choose the appropriate dilution for your needs.
Immunogen	A synthesized peptide.
MW	87 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
Tissue specificity	Expressed in a variety of leukocyte lines.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P26010