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Rabbit Anti-ITGAM Polyclonal Antibody#abs132920

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Description

Catalog-specification	Delivery time	USD price
abs132920-50ug	1-2 Weeks	201.0
abs132920-100ug	1-2 Weeks	301.0

Overview
catalog	abs132920
Other names	The antigen CD11b, also known as p170, is a glycoprotein that belongs to the CD11 antigen-like family. It is encoded by the ITGAM gene and is also referred to as complement component receptor 3 alpha (CR3A). CD11b is a subunit of the cell surface glycoprotein MAC-1 and is also a subunit of the integrin beta 2 alpha subunit. CD11b is expressed on various leukocytes, including neutrophils, monocytes, and macrophages. It plays a crucial role in leukocyte adhesion and migration, as well as phagocytosis. CD11b is involved in the clearance of complement-opsonized particles, and its deficiency has been linked to an increased risk of infection. In addition to its role in innate immunity, CD11b has also been implicated in various pathological conditions, including autoimmune diseases like systemic lupus erythematosus (SLE). It is a potential therapeutic target for these diseases, and its targeting could help reduce inflammation and tissue damage. Overall, CD11b is a crucial molecule in the immune system and has important physiological and pathological roles. Further research is needed to fully understand its functions and potential therapeutic applications.
Source	Rabbit
Specificity	The ITGAM antibody is capable of identifying the overall amount of endogenous ITGAM present within a sample. This means that it can accurately detect the total ITGAM levels without any external interference. In order to generate a similarly worded content, the original text has been rearranged and rephrased to reflect the same information with different phrasing and sentence structures.
Species Reactivity	Human
Antigen	ITGAM
Application	The recommended dilution for Western blotting is between 1:500 and 1:2000, while for immunohistochemistry it is between 1:50 and 1:200. For ELISA assays using a peptide, a dilution of between 1:20000 and 1:40000 is suggested. It is important to follow these guidelines to ensure accurate and reliable results in your experiments. Dilutions outside of the recommended range may lead to non-specific binding or a lack of signal. Always validate your dilution series and optimize as necessary to achieve the best results for your specific application.
Immunogen	A synthesized peptide.
MW	170 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Tissue specificity	Predominantly expressed in monocytes and granulocytes.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P11215