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Rabbit Anti-ITGA2B Polyclonal Antibody#abs136968

Please note that the price provided is only for your reference. For detailed pricing, we kindly request you to get in touch with our seller, Vecent. Feel free to reach out to Vecent for more information. Western blot analysis of extracts of various celllines, using ITGA2B antibody. This product...

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Description

Catalog-specification	Delivery time	USD price
abs136968-100ug	1-2 Weeks	301.0
abs136968-50ug	1-2 Weeks	201.0

Overview
catalog	abs136968
Description	Alpha chain 2b, encoded by ITGA2B, is a vital component of integrins. Integrins are integral membrane proteins that consist of an alpha chain and a beta chain, forming a heterodimer. Post-translational cleavage of the alpha chain 2b results in the production of disulfide-linked light and heavy chains. These chains combine with beta 3 to create a fibronectin receptor present in platelets, which plays a critical role in the coagulation process. Thrombasthenia occurs when mutations disrupt this important function. Integrins not only function in adhesion but also participate in cell-surface mediated signaling pathways.
Other names	CD41 antigen is also known by several other names such as BDPLT16, BDPLT2, CD41B, form 2, GP2B, GPalpha IIb, GPIIb, GT, GTA, HPA3, Integrin alpha 2b, Integrin alpha IIb, Integrin alpha-IIb light chain, Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), ITA2B_HUMAN, Itga2b, ITGAB, platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb of IIb/IIIa complex, Platelet membrane glycoprotein IIb, platelet specific antigen BAK, PPP1R93. Feel free to generate the desired content using the rearranged information provided above!
Source	Rabbit
Specificity	The total ITGA2B, present at endogenous levels, can be effectively detected using the ITGA2B Antibody. To create a highly similar content, we can rearrange the sentence as follows: The ITGA2B Antibody is capable of detecting the total ITGA2B protein in its natural quantities within the organism.
Species Reactivity	Human;Rat
Predictive reaction species	Horse
Antigen	ITGA2B
Application	The dilution factors for Western Blotting (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000. It is important to note that the dilution factors provided should be followed as they are crucial for the accuracy and effectiveness of the experimental techniques mentioned. Can I help you with anything else?
Immunogen	A synthesized peptide derived from human ITGA2B.
MW	113kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Tissue specificity	Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974).
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P08514