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Rabbit Anti-IL17F Polyclonal Antibody#abs138501

Please note that the price provided above is for reference purposes only. For detailed pricing information, we kindly ask you to reach out to our seller Vecent. Thank you for your understanding. Western blot analysis IL17F using HeLa whole cell lysates This product is for research use only, not...

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Description

Catalog-specification	Delivery time	USD price
abs138501-100ug	1-2 Weeks	301.0
abs138501-50ug	1-2 Weeks	201.0

Please note that the price provided above is for reference purposes only. For detailed pricing information, we kindly ask you to reach out to our seller Vecent. Thank you for your understanding.

Overview
catalog	abs138501
Other names	IL-17F, also known as interleukin-17F or cytokine ML-1, is a cytokine that plays a role in immunity and inflammation. It is closely related to IL-17A and is produced by certain T cells and other immune cells. Mutant IL-17F has also been identified and studied. Another cytokine, IL-24, has also been linked to immune regulation and has been studied for its potential therapeutic applications. These cytokines and their functions are important areas of research in the field of immunology.
Source	Rabbit
Specificity	Total IL17F is detected by IL17F Antibody at endogenous levels.
Species Reactivity	Human
Antigen	IL17F
Application	For western blot, the recommended dilution range is 1:1000 to 1:3000, while for immunohistochemistry, a 1:200 dilution is recommended. For ELISA using peptides, the recommended dilution range is quite high, at 1:20000 to 1:40000. It is important to follow these recommended dilutions to ensure accurate and reliable results. Diluting the reagents too much or not enough can lead to false positives or false negatives, which can be detrimental to the success of the experiment. Therefore, it is crucial to be precise and consistent in the dilution of these reagents.
Immunogen	A synthesized peptide derived from human IL17F.
MW	18 kDa
Properties
Concentration	1mg/ml
purification	The purification of the antiserum involved the use of SulfoLink™ Coupling Resin for peptide affinity chromatography. Through this method, the antiserum was able to be isolated and purified effectively.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product's quality, it is recommended to store it at -20 °C for one year. It is important to avoid subjecting it to repeated freezing and thawing.
Storage buffer	This product is Rabbit IgG in a solution consisting of phosphate buffered saline with a pH of 7.4, 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. Our recommendation is to store it at -20°C, as it will remain stable for up to 12 months from the date of receipt. Please ensure that you follow the correct storage instructions to maintain the product's effectiveness.
Target
Background	Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).
Tissue specificity	Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Celluar localization	Extracellular region or secreted;
UniPort	Q96PD4