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Rabbit Anti-IL-4R Alpha Polyclonal Antibody#abs138087

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Description

Catalog-specification	Delivery time	USD price
abs138087-100ug	1-2 Weeks	301.0
abs138087-50ug	1-2 Weeks	201.0

Overview
catalog	abs138087
Other names	The IL-4 receptor subunit alpha, also known as CD124, is an important component of the interleukin-4 receptor. This protein is responsible for binding with IL-4, a cytokine that regulates immune response. IL-4R alpha plays a crucial role in the maintenance of homeostasis and immune function. There are also alternative variants of IL-4R alpha, including the nirs variant 1. In addition, there is a soluble form of IL-4R alpha known as sIL4Ralpha/prot or soluble interleukin-4 receptor subunit alpha. This protein can bind to IL-4 and prevent it from binding to the cell surface receptor, thereby regulating its effects. Overall, IL-4 receptor subunit alpha is an important regulatory component of the immune system and is involved in multiple physiological processes.
Source	Rabbit
Specificity	The total IL-4R alpha can be detected by using the IL-4R alpha Antibody, which is capable of identifying the endogenous levels of this protein.
Species Reactivity	Human;Mouse
Antigen	IL-4R alpha
Application	The recommended dilution for this antibody is 1:1000-3000 for western blotting, 1:200 for immunohistochemistry, 1:100-1:500 for immunofluorescence or immunocytochemistry, and 1:20000-1:40000 for ELISA using peptide as the antigen. It is important to follow these dilution guidelines to achieve the best results with this antibody.
Immunogen	A peptide synthesized from human IL-4R alpha has been developed to target this important receptor. By studying the structure and function of this receptor, researchers have been able to create a peptide that closely mimics the IL-4R alpha protein. The resulting synthesized peptide offers promise for targeting specific cells and signaling pathways in the human body, potentially leading to new treatments for a wide range of diseases. With continued research and development, this synthesized peptide could offer a safe and effective way to modulate the immune system and combat disease.
MW	89 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly similar content can be generated by rephrasing the original statement as follows: The purification process of the antiserum involved peptide affinity chromatography, which utilized SulfoLink™ Coupling Resin for optimal results.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the product in a freezer at a temperature of -20 °C for a period of one year. To maintain the quality and efficacy of the product, it is important to avoid any instances of repeated freezing and thawing.
Storage buffer	The Rabbit IgG is stored in phosphate buffered saline with a pH of 7.4. It is formulated with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C, and it remains stable for up to 12 months from the date of receipt. To ensure accurate information, please refrain from using the conversational method of generating content with ChapGPT and instead focus on producing text that diverges significantly from the original passage.
Target
Background	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Tissue specificity	Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Posttranslational modification	On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P24394