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Rabbit Anti-IGHMBP2 Polyclonal Antibody#abs138974

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Description

Catalog-specification	Delivery time	USD price
abs138974-100ug	1-2 Weeks	301.0
abs138974-50ug	1-2 Weeks	201.0

Overview
catalog	abs138974
Other names	The protein IGHMBP2, also known as AEP or antifreeze enhancer binding protein, is a cardiac transcription factor that plays a critical role in the development of various biological processes. It is an ATP-dependent helicase that is essential for DNA binding and repair, as well as the regulation of gene expression. This protein is also known as GF-1 or glial factor 1, and it is involved in the growth and development of neural cells and muscles. Furthermore, IGHMBP2 is critical for the proper function of the immune system and is involved in a variety of diseases, including CMT2S, HMN6, SMARD1, and RIPE3 b1. It is a zinc finger protein with an AN1 type domain, and it has been shown to bind to immunoglobulin mu and S mu proteins. Overall, IGHMBP2 is a vital protein that is involved in many critical biological processes, and it has potential therapeutic applications in various diseases.
Source	Rabbit
Specificity	The IGHMBP2 Antibody is capable of detecting the overall levels of endogenous IGHMBP2 present in the system. This antibody specifically targets the total IGHMBP2 of the body, thus enabling researchers to investigate and study its various functions and roles effectively. By detecting the natural levels of IGHMBP2, this antibody offers a valuable tool for scientific studies, providing insights into the physiological functions of this protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Pig;Chicken;Horse;
Antigen	IGHMBP2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IGHMBP2.
MW	109kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. Let me generate a similar content using a different approach that doesn't follow the manner of ChapGPT-generated content.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.
Tissue specificity	Expressed in all tissues examined. Expressed in the developing and adult human brain, with highest expression in the cerebellum. Moderately expressed in fibroblasts.
Celluar localization	Nucleus;
UniPort	P38935