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Rabbit Anti-PSRC1 Polyclonal Antibody#abs136878

Please note that the price mentioned above is for your reference only. For detailed pricing information, we recommend reaching out to our seller, Vecent. Kindly contact Vecent for precise pricing details. Western blot analysis of extracts of various celllines, using PSRC1 antibody. This product...

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Description

Catalog-specification	Delivery time	USD price
abs136878-100ug	1-2 Weeks	301.0
abs136878-50ug	1-2 Weeks	201.0

Overview
catalog	abs136878
Description	This particular genetic sequence is responsible for producing a protein abundant in proline. Extensive research on both the human and mouse versions of this gene indicates that it is under the control of a protein called p53. Additionally, it appears to play a role in inhibiting growth as directed by p53. The protein synthesized by this gene is thought to regulate the dynamics of microtubules, which are vital components of cell division. It accomplishes this by attracting and managing microtubule depolymerases that contribute to the breakdown of these structures. Interestingly, there is evidence linking a specific genetic variation in this gene to reduced levels of low-density lipoprotein cholesterol in the bloodstream. It's worth noting that various forms of this gene's transcript have been identified, leading to the production of different isoforms of the encoded protein.
Other names	DDA3, also known as mouse homolog of, is a gene that is activated by p53 and is involved in the process of differential display. It is represented by the protein FP3214 and has two alternative names, OTTHUMP00000013785 and OTTHUMP00000013786. DDA3 is a p53-regulated gene and is also referred to as Proline/serine-rich coiled-coil 1 or PSRC1. The protein encoded by DDA3 is known for its proline/serine-rich coiled-coil structure.
Source	Rabbit
Specificity	The PSRC1 Antibody is designed to identify and measure the amount of total PSRC1 present in an organism's cells. By detecting endogenous levels of this protein, the antibody can provide valuable insights into cellular processes and functions. To ensure the accuracy of your results, it is important to use a highly specific and reliable antibody such as the PSRC1 Antibody. With its ability to detect even trace amounts of PSRC1, this antibody can be an invaluable tool in your research efforts.
Species Reactivity	Human;Rat
Antigen	PSRC1
Application	The suggested dilutions for WB are from 1:500 to 1:2000, for IHC from 1:50 to 1:200, and for ELISA (peptide) from 1:20000 to 1:40000. To recap, a 1:500 dilution is recommended as a starting point for WB, with a range up to 1:2000. For IHC, a dilution of 1:50 to 1:200 is suitable. Finally, for ELISA (peptide), the dilution range should be from 1:20000 to 1:40000. These dilutions will ensure the best possible results for your experiments.
Immunogen	A synthesized peptide derived from human PSRC1.
MW	38kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. This process resulted in a highly refined form of the original compound.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Tissue specificity	Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.
Posttranslational modification	Phosphorylated during mitosis.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q6PGN9