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Rabbit Anti-Histone H2AZ Polyclonal Antibody#abs133385

Rabbit Anti-Histone H2AZ Polyclonal Antibody#abs133385

Please be informed that the price mentioned above is provided for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specificationDelivery timeUSD price

abs133385-100ug

1-2 Weeks

301.0

abs133385-50ug

1-2 Weeks

201.0

Please be informed that the price mentioned above is provided for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.


Overview

catalog

abs133385
Other namesHistone H2A.Z, also known as H2A histone family member Z, H2A/z, H2afz, H2AZ, H2AZ_HUMAN, and MGC117173, is a protein that plays a crucial role in the regulation of gene expression and chromatin remodeling. This protein is highly conserved across many species and is involved in a wide range of biological processes, including DNA repair, embryonic development, and cellular differentiation. H2A.Z is known to interact with multiple cellular proteins, including DNA-binding transcription factors, chromatin-remodeling complexes, and histone-modifying enzymes. Its functions are also known to be regulated by various post-translational modifications such as phosphorylation, acetylation, and methylation. Further research on H2A.Z may provide insights into the mechanisms of gene expression regulation and the development of novel therapies for human diseases.
SourceRabbit
SpecificityThe Histone H2AZ Antibody is designed to recognize total Histone H2AZ present at endogenous levels.
Species ReactivityHuman;Mouse;Rat
AntigenHistone H2AZ
ApplicationWB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
ImmunogenA synthesized peptide.
MW13 KD
Properties

Concentration

1mg/ml

purificationUsing SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
ClonalityPolyclonal Antibody
Stability & StorageTo ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles during storage.
Storage bufferThis solution contains Rabbit IgG in a phosphate buffered saline with a pH of 7.4 and 150mM NaCl. It also contains 0.02% sodium azide and 50% glycerol. It is recommended to store this solution at a temperature of -20 °C for optimal stability. It can remain stable for a period of up to 12 months from the date of receipt.

Target

Background

Conventional H2A is replaced by a variant histone H2A in a specific subset of nucleosomes. These nucleosomes are responsible for wrapping and compacting DNA into a structure known as chromatin. The compact nature of chromatin limits access to DNA by cellular machineries that require DNA as a template. As a result, histones, including variant H2A, play a crucial role in regulating processes such as transcription, DNA repair, DNA replication, and maintaining chromosomal stability. The regulation of DNA accessibility is controlled by a complex array of modifications known as the histone code, along with nucleosome remodeling. It is possible that variant histone H2A is involved in the formation of constitutive heterochromatin. Additionally, it may be necessary for ensuring proper chromosome segregation during cell division.

Posttranslational modificationMonoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.Not phosphorylated.
Celluar localizationExtracellular region or secreted;Nucleus;
UniPortP0C0S5


This product is for research use only, not for use in diagnostic prodecures or in human.


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