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Rabbit Anti-GRK6 Polyclonal Antibody#abs133482

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Description

Catalog-specification	Delivery time	USD price
abs133482-100ug	1-2 Weeks	301.0
abs133482-50ug	1-2 Weeks	201.0

Overview
catalog	abs133482
Other names	GRK6 is an abbreviation for G protein-coupled receptor kinase 6, also known as G protein coupled receptor kinase GRK6 or GPRK6. GRK6 is a human protein involved in the phosphorylation of G protein-coupled receptors. This protein plays a crucial role in regulating cellular responses to various stimuli. Understanding the functions and mechanisms of GRK6 can provide valuable insights into cell signaling pathways and potential therapeutic targets. Studying GRK6 can contribute to the development of new drugs targeting G protein-coupled receptors and associated diseases.
Source	Rabbit
Specificity	The detection of endogenous levels of total GRK6 is made possible using the GRK6 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Zebrafish;Chicken;Pig;Sheep;Horse;Bovine;Rabbit;
Antigen	GRK6
Application	The recommended dilutions for WB are 1:500~1:1000, while for IF/ICC, they are 1:100-1:500. For ELISA using peptide, the appropriate dilutions are 1:20000-1:40000. It is important to note that these dilutions are based on the original text information and should be followed closely to obtain accurate results in your experiments. Be sure to adjust the dilutions as needed based on your particular assay and sample type.
Immunogen	A synthesized peptide.
MW	65 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography. Let me generate a highly similar content by rearranging the above information while ensuring it stays accurate.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and is considered stable for a period of 12 months starting from the date of receipt.
Target
Background	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Tissue specificity	Widely expressed.
Posttranslational modification	It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
Celluar localization	Plasma Membrane;
UniPort	P43250