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Rabbit Anti-GPT2 Polyclonal Antibody#abs138703

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Description

Catalog-specification	Delivery time	USD price
abs138703-100ug	1-2 Weeks	301.0
abs138703-50ug	1-2 Weeks	201.0

Overview
catalog	abs138703
Other names	ALAT2_HUMAN, also known as alanine aminotransferase 2 or ALT2, is an enzyme that plays an important role in the metabolism of amino acids. It belongs to the family of aminotransferases and is responsible for the transfer of an amino group from alanine to alpha-ketoglutarate, resulting in the creation of pyruvate. In addition to the primary function of catalyzing the transamination of amino acids, ALAT2_HUMAN also has a secondary role in the synthesis of glucose through the gluconeogenesis pathway. It is predominantly expressed in the liver, but can also be found in other tissues such as the kidney and heart. The gene encoding for ALAT2_HUMAN is located on chromosome 16 and contains 12 exons. Mutations in this gene have been associated with an increased risk of developing liver diseases such as nonalcoholic fatty liver disease and cirrhosis. Overall, ALAT2_HUMAN is a crucial enzyme involved in various metabolic processes. Further study of its function and regulation may lead to new insights into the development and treatment of liver diseases.
Source	Rabbit
Specificity	To detect the total GPT2 present in the body, the GPT2 Antibody is used which can bind to the endogenous levels of this protein. This process helps in analyzing the quantity of GPT2 in the human body by detecting it through the use of the specific antibody that recognizes this protein. By utilizing this technology, researchers are able to gain a deeper understanding of the role that GPT2 plays in various cellular processes and how it may contribute to the development of certain diseases.
Species Reactivity	Human
Predictive reaction species	Dog
Antigen	GPT2
Application	WB 1:1000-3000，IF/ICC 1:100-1:500，ELISA（）1:20000-1:40000。，，。
Immunogen	A synthesized peptide derived from human GPT2.
MW	58 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. The resulting product was highly purified and free of impurities.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain product quality, it is recommended to store at a temperature of -20 °C for a duration of one year while avoiding any freeze/thaw cycles. It is important to note that repeated freezing and thawing should be avoided to ensure product stability.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline, mixed with 0.02% sodium azide, 150mM NaCl, and 50% glycerol. It is recommended to store this product at -20 °C for optimal stability, and it should remain stable for up to 12 months from the time of receipt.
Target
Background	Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
Tissue specificity	Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.
Celluar localization	Mitochondrion;
UniPort	Q8TD30