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Rabbit Anti-AGXT2 Polyclonal Antibody#abs138704

Description

Catalog-specification	Delivery time	USD price
abs138704-100ug	1-2 Weeks	301.0
abs138704-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. It is important to keep in mind that the content generated should be based on the original text, however, it should be rephrased using a highly similar style to ensure clarity and understanding. Please refrain from using ChapGPT to generate content and instead utilize language models that produce distinct narratives.

Overview
catalog	abs138704
Other names	AGT2, also known as (R)-3-amino-2-methylpropionate--pyruvate transaminase, AI303810, AI663818, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, and DAIBAT, is an important enzyme in the body that plays a crucial role in amino acid metabolism. This enzyme is mainly involved in the conversion of alanine and glyoxylate into pyruvate and glycine, which are essential compounds for the body. The activity of AGT2 is particularly important in the liver and kidneys, where it helps to maintain proper levels of these critical amino acids. Interestingly, there are actually two distinct forms of AGT2 that have been identified: a cytoplasmic version and a mitochondrial version. While the cytoplasmic version is primarily responsible for the metabolism of alanine and glyoxylate, the mitochondrial version is involved in the breakdown of other amino acids such as serine and threonine. Both forms of the enzyme are essential for proper amino acid metabolism and overall health. Despite its importance, AGT2 is also associated with certain health conditions when it is not functioning correctly. For example, mutations in the gene that codes for this enzyme can lead to a rare genetic disorder called primary hyperoxaluria type 1. This condition is characterized by the buildup of oxalate in the kidneys, which can cause kidney damage and other complications if left untreated. Overall, AGT2 is a critical enzyme that plays an important role in amino acid metabolism and overall health. Further research into the function and regulation of this enzyme could have important implications for the diagnosis and treatment of certain health conditions.
Source	Rabbit
Specificity	The AGXT2 Antibody is capable of detecting overall levels of AGXT2 that exist naturally within a sample. To rephrase this statement, the content can be rearranged to say that the AGXT2 Antibody can detect endogenous levels of total AGXT2.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Bovine;
Antigen	AGXT2
Application	The recommended dilutions for Western blot (WB) range from 1:1000 to 1:3000. For Immunohistochemistry (IHC), the suggested dilution is 1:200, while for Immunofluorescence (IF), the optimal dilution is also 1:200. In the case of ELISA using a peptide substrate, the dilution range is between 1:20000 and 1:40000.
Immunogen	A synthesized peptide derived from human AGXT2.
MW	57 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store the item at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the item to repeated cycles of freezing and thawing. This will help to ensure the optimal storage conditions are maintained and the item remains in good condition for future use.
Storage buffer	Phosphate buffered saline containing rabbit IgG is a solution with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This solution should be stored at -20 °C and is considered stable for a duration of 12 months starting from the date of receipt.
Target
Background	Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Celluar localization	Mitochondrion;
UniPort	Q9BYV1