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Rabbit Anti-GDF11 Polyclonal Antibody#abs137841

Please note that the price mentioned is only for your reference. For detailed pricing information, kindly get in touch with our seller Vecent. Western blot analysis GDF11 using MCF7 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs137841-100ug	1-2 Weeks	301.0
abs137841-50ug	1-2 Weeks	201.0

Please note that the price mentioned is only for your reference. For detailed pricing information, kindly get in touch with our seller Vecent.

Overview
catalog	abs137841
Other names	BMP 11, also known as BMP-11 or Bone Morphogenetic Protein 11, is a protein that plays an important role in regulating the growth and differentiation of cells in the body. Additionally, it is also known as GDF 11, or Growth Differentiation Factor 11, with its abbreviation being GDF-11. This particular protein, GDF11_HUMAN, is responsible for the growth and development of various tissues and organs within the body. It is involved in the regulation of bone density, muscle mass, and cardiovascular function, among other things. GDF 11 is also known for its ability to stimulate the growth of new blood vessels, which is important for the proper functioning of many organs and tissues. While much is still unknown about the precise functions of BMP-11, scientists are continuing to study this protein in the hopes of uncovering new insights into its role in the body. It is believed that a better understanding of BMP 11 could lead to the development of new therapies and treatments for a range of different health conditions, from bone disorders to cardiovascular disease.
Source	Rabbit
Specificity	Our GDF11 Antibody is designed to specifically detect the total endogenous levels of GDF11.
Species Reactivity	Human;Mouse
Predictive reaction species	Zebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
Antigen	GDF11
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human GDF11.
MW	45 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography in order to purify the antiserum. Please rearrange the provided content and ensure that the generated content remains closely aligned with the original information.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve its quality, it is recommended to store the product at a temperature of -20 °C for a period of one year. Please be sure to avoid any instances of repeatedly freezing and thawing the product to maintain its effectiveness.
Storage buffer	The recommended storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4 and a solution containing 150mM NaCl. To maintain stability, it is important to add 0.02% sodium azide and 50% glycerol to the storage solution. This ensures that the Rabbit IgG remains stable for a period of 12 months from the date of receipt. It is essential to carefully adhere to these storage instructions in order to maintain the integrity and functionality of the Rabbit IgG.
Target
Background	Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
Posttranslational modification	Synthesized as large precursor molecule that undergoes proteolytic cleavage. The mature C-terminal portion of the molecule is bound non-covalently to its N-terminal propeptide rendering it inactive. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	O95390