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Rabbit Anti-CCRL1 Polyclonal Antibody#abs140620

Please note that the mentioned price is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. We recommend contacting Vecent to obtain accurate pricing details. Western blot analysis of extracts from HepG2 cells, using CCRL1 antibody. This...

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Description

Catalog-specification	Delivery time	USD price
abs140620-50ug	1-2 Weeks	201.0
abs140620-100ug	1-2 Weeks	301.0

Overview
catalog	abs140620
Other names	Atypical chemokine receptor 4, also known as ACKR4, is a protein that acts as a receptor for chemokines in the CC family. This receptor is also referred to as C-C chemokine receptor type 11, CCRL1 or CCR10. The protein is encoded by the CCRL1 gene in humans and is part of the larger family of G protein-coupled receptors (GPCRs). ACKR4 is an orphan seven-transmembrane receptor chemokine related protein and is structurally diverse from other chemokine receptors. It has been shown to play an important role in immune system regulation, specifically in the maintenance of dendritic cell homeostasis. In addition, ACKR4 also plays a role in various physiological processes such as hematopoiesis, inflammation, and cancer development. Furthermore, ACKR4 is known to be expressed in a variety of tissues including the spleen, thymus, lymph nodes, and bone marrow, highlighting its importance in the immune system. Its expression has also been observed in the lung, liver, and kidney. The role of ACKR4 has been extensively studied, and it has been shown to modulate the activity of chemokines, thereby playing a crucial role in inflammation and immune cell migration. In summary, ACKR4 is a crucial protein that plays a significant role in immune regulation, inflammation, and cancer development. Its expression in various tissues highlights its importance, and further research on this protein could lead to the development of novel treatments for various diseases.
Source	Rabbit
Specificity	The CCRL1 Antibody is designed to recognize and bind to all forms of CCRL1 present in living organisms. Its sensitivity allows for detection of endogenous levels of total CCRL1 protein, providing a valuable tool for researchers studying this important protein.
Species Reactivity	Human;Mouse;Rat
Antigen	CCRL1
Application	We recommend using a dilution of WB 1:500~1:1000 for optimal results, and for IF/ICC a dilution of 1:100-1:500 is suggested. For ELISA assays using peptide substrates, we highly recommend a dilution of 1:20000-1:40000. These dilution recommendations are based on the original text information and have been proven to yield the best results for the specified applications. Please note that other factors such as sample quality and assay sensitivity may need to be taken into account when interpreting results.
Immunogen	A synthesized peptide.
MW	40 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly purified antiserum was obtained through this process.
Clonality	Polyclonal Antibody
Stability & Storage	To keep this product in optimal condition, it is important to store it at a temperature of -20 °C for up to one year. It is highly recommended to avoid subjecting the product to repeated freeze/thaw cycles, as this can undermine its effectiveness and quality. Remember to take these precautions so that you can derive maximum benefit from this product.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline at pH 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C, and will remain stable for up to 12 months from the date of receipt. This information is important for those who work with Rabbit IgG, as it ensures that the solution maintains its quality and effectiveness over time. Proper storage is essential for optimal results, and this specific solution is designed to meet the needs of researchers in a variety of fields.
Target
Background	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
Tissue specificity	Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
Posttranslational modification	The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
Celluar localization	Endosome;Plasma Membrane;
UniPort	Q9NPB9