Rabbit Anti-Ferritin Heavy Chain Polyclonal Antibody#abs137182
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Description
| Catalog-specification | Delivery time | USD price |
abs137182-100ug | 1-2 Weeks | 301.0 |
abs137182-50ug | 1-2 Weeks | 201.0 |
Note: The provided price is only for your reference, for detailed pricing information, please get in touch with our sales representative, Vecent. To ensure that the generated content is substantially different from the original text, I will generate a speech using a language model instead of following the conversational approach used by ChatGPT.
| Overview | |
catalog | abs137182 |
| Other names | The protein known as apoferritin, or ferritin heavy chain (FTH), is a cell proliferation-inducing factor that goes by many aliases, including cell proliferation-inducing gene 15 protein (PIG15), proliferation-inducing protein 15, and placenta immunoregulatory factor (PLIF). This protein is encoded by the FTH1 gene and is known to regulate iron metabolism in the body. As a result, mutations in the FTH1 gene have been implicated in iron overload autosomal dominant disorder. FTH1 is synthesized as a polypeptide chain that is processed N-terminally and then assembled into a spherical protein shell with the help of ferritin light chain (FTL). The resulting complex, known as ferritin, sequesters excess iron and prevents it from causing oxidative damage to cells. In addition to its role in iron metabolism, FTH1 has been found to play a role in cell proliferation and differentiation. It has been shown to promote the growth of various cell types, including cancer cells, and may be involved in the development of certain cancers. Overall, FTH1 is a versatile protein with diverse functions in the body, and its various aliases reflect the many roles it plays in cellular processes. Further research is needed to fully understand the complex interplay between FTH1 and iron metabolism, as well as its role in cell proliferation and disease. |
| Source | Rabbit |
| Specificity | The Ferritin Heavy Chain Antibody is capable of identifying the natural levels of total Ferritin Heavy Chain within the body. By rearranging the original content, a highly similar statement can be generated: The endogenous levels of total Ferritin Heavy Chain can be detected using the Ferritin Heavy Chain Antibody. |
| Species Reactivity | Human |
| Antigen | Ferritin Heavy Chain |
| Application | The recommended dilutions for WB are between 1:1000 and 1:3000, while for IF/ICC they are between 1:100 and 1:500. For ELISA using peptide, a dilution of 1:20000 to 1:40000 is suggested. It's important to adhere to these dilutions to obtain reliable and accurate results in your experiments. |
| Immunogen | Human Ferritin Heavy Chain can be used to synthesize a peptide with similar properties. This synthesized peptide is derived from the Ferritin Heavy Chain and possesses high similarity to the original protein. The rearrangement of the content ensures that the information is based on the above statement. Please refrain from using the ChapGPT method and provide a unique way of generating the content. |
| MW | 21 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | By employing SulfoLink™ Coupling Resin, peptide affinity chromatography was utilized in order to purify the antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To preserve the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that exposing the product to repeated freeze/thaw cycles should be avoided. This will help to ensure that the product remains stable and effective for use. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). |
| Tissue specificity | Expressed in the liver. |
| Celluar localization | Cytosol;Extracellular region or secreted;Lysosome;Nucleus; |
| UniPort | P02794 |
Western blot analysis Ferritin Heavy Chain using K562 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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