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Rabbit Anti-FCER1A Polyclonal Antibody#abs136113

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Description

Catalog-specification	Delivery time	USD price
abs136113-100ug	1-2 Weeks	301.0
abs136113-50ug	1-2 Weeks	201.0

Overview
catalog	abs136113
Description	The high affinity IgE receptor, also known as Fc fragment of IgE, alpha polypeptide, or FCER1A, is a crucial component involved in allergic diseases like asthma and hay fever. This single-pass type I membrane protein consists of two immunoglobulin-like domains. It forms a complex with other subunits, including one glycosylated alpha chain (FCER1A), one beta chain (FCER1B), and two gamma chains (FCER1G), to create the IgE receptor. Through this receptor, allergens and mast cells are connected, triggering immediate hypersensitivity and inflammatory responses. Understanding the role of FCER1A in these disorders is vital for elucidating the mechanisms that drive allergic reactions.
Other names	The Fc epsilon RI alpha chain, also known as the Fc fragment of IgE high affinity I receptor for alpha polypeptide, is an important component of the high affinity IgE receptor. It plays a crucial role in the immune response by binding to immunoglobulin E (IgE) and triggering allergic reactions. The Fc epsilon RI alpha-chain is responsible for the recognition and binding of IgE antibodies, which are produced in response to allergens. By interacting with IgE, it initiates a cascade of events that ultimately lead to the release of inflammatory mediators, such as histamine, from mast cells and basophils. This receptor subunit, encoded by the FCER1A gene, is expressed on a variety of immune cells, including mast cells, basophils, and antigen-presenting cells. It consists of two extracellular domains, a transmembrane domain, and a cytoplasmic tail that contains signaling motifs. The Fc epsilon RI alpha polypeptide is a critical component of the Fc epsilon RI complex, which also includes beta and gamma subunits. Together, these subunits form a functional receptor complex that transduces signals upon IgE binding. Understanding the structure and function of the Fc epsilon RI alpha chain is essential for developing therapies targeting allergic diseases. By modulating its activity, researchers aim to alleviate the symptoms associated with conditions like asthma, allergic rhinitis, and atopic dermatitis.
Source	Rabbit
Specificity	The FCER1A Antibody is capable of detecting the total amount of endogenous FCER1A present within a sample. The content can be reworded and rearranged to read: The total level of endogenous FCER1A can be identified using the FCER1A Antibody.
Species Reactivity	Human;Rat
Antigen	FCER1A
Application	For Western blotting, the recommended dilution ranges from 1:500 to 1:2000. When it comes to immunohistochemistry, the suggested dilution is between 1:50 and 1:200. If you are using ELISA with a peptide, it is advised to dilute from 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human FCER1A.
MW	30kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Celluar localization	Plasma Membrane;
UniPort	P12319