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Rabbit Anti-ESRP1 Polyclonal Antibody#abs137755

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Description

Catalog-specification	Delivery time	USD price
abs137755-100ug	1-2 Weeks	301.0
abs137755-50ug	1-2 Weeks	201.0

Overview
catalog	abs137755
Other names	Esrp1, also known as epithelial splicing regulatory protein 1, is a human protein. It is encoded by the FLJ20171 gene and is also referred to as RBM35A or RNA binding motif protein 35A. Esrp1 acts as an RNA-binding protein, involved in the regulation of splicing. Its role in epithelial cells is particularly significant as it promotes the proper alternative splicing of various target genes. This protein plays a crucial role in maintaining epithelial cell identity and function. By rearranging the content, we can gain a better understanding of Esrp1 and its involvement in cellular processes.
Source	Rabbit
Specificity	The total levels of endogenous ESRP1 can be reliably detected using the ESRP1 Antibody. One can rearrange the given information to say that the antibody is capable of specifically identifying and measuring the natural levels of ESRP1 within cells or tissues.
Species Reactivity	Human
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	ESRP1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ESRP1.
MW	76 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the product is kept at -20 °C for a period of one year to maintain its stability. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles, as this may lead to potential deterioration.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline, pH 7.4, with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is important to keep this compound stored at -20 °C for optimal stability. This product is stable for 12 months from the date of receipt. Ensure that you follow the storage guidelines to maintain the efficacy of this product.
Target
Background	mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Tissue specificity	Epithelial cell-specific.
Celluar localization	Nucleus;
UniPort	Q6NXG1