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Rabbit Anti-EIF4G1 Polyclonal Antibody#abs137092

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Description

Catalog-specification	Delivery time	USD price
abs137092-100ug	1-2 Weeks	301.0
abs137092-50ug	1-2 Weeks	201.0

Overview
catalog	abs137092
Other names	1. eIF-4G1, also known as EIF4 gamma 1 or eukaryotic translation initiation factor 4 gamma 1, plays a crucial role in protein synthesis. 2. EIF4G1 acts as a key component of the EIF4F complex, which aids in the initiation of mRNA translation. 3. With its involvement in translation initiation, EIF4G1 facilitates the recruitment of ribosomes to mRNA and enables efficient protein synthesis. 4. This protein, encoded by the DKFZp686A1451 gene, is commonly referred to as eIF-4G1 or p220. 5. The function of EIF4G1 is vital for various cellular processes and is essential for proper gene expression. 6. The significance of EIF4G1 lies in its ability to regulate translation, allowing cells to efficiently produce proteins necessary for their growth and survival. 7. Through its interactions with other translation initiation factors, EIF4G1 plays a critical role in coordinating efficient protein synthesis. 8. EIF4G1 is considered a promising target for therapeutic interventions aiming to modulate protein synthesis in various disease conditions. 9. Understanding the precise role and regulation of EIF4G1 is crucial for advancing our knowledge of cellular processes and developing potential therapeutic strategies. 10. In summary, EIF4G1, also known as eIF-4G1 or p220, is an essential component of the translation initiation machinery, playing a vital role in protein synthesis and cellular function.
Source	Rabbit
Specificity	The EIF4G1 Antibody is designed to detect total levels of endogenous EIF4G1 protein. By using this antibody, researchers can identify and measure the amount of EIF4G1 present in their samples accurately. This information is crucial for understanding the role of EIF4G1 in various biological processes.
Species Reactivity	Human
Antigen	EIF4G1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human EIF4G1.
MW	220 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography for purification. A highly pure antiserum was obtained through this process.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store at a temperature of -20 °C for a duration of one year. It is crucial to prevent the product from undergoing multiple freeze/thaw cycles.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline (pH 7.4) with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C to maintain its stability. The product is guaranteed to be stable for a period of 12 months from the date of receipt.
Target
Background	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Posttranslational modification	Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
Celluar localization	Cytosol;Nucleus;
UniPort	Q04637