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Rabbit Anti-EIF2C3 Polyclonal Antibody#abs139028

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Description

Catalog-specification	Delivery time	USD price
abs139028-100ug	1-2 Weeks	301.0
abs139028-50ug	1-2 Weeks	201.0

Overview
catalog	abs139028
Other names	The protein encoded by the gene 5730550L01Rik is known as Argonaute 3 or Ago3. It is also referred to as eIF-2C 3, eIF2C 3, or Eukaryotic translation initiation factor 2C 3. This protein is a member of the Argonaute family and is involved in gene silencing through RNA interference. It plays a crucial role in the regulation of gene expression and is essential for proper development and function of cells. AGO3_HUMAN is the human version of this protein. Other names for Ago3 include Eif2c3, EIF2C3 protein, Eukaryotic translation initiation factor 2C3, FLJ12765, hAgo3, MGC86946, and Protein argonaute-3. Understanding the function of Ago3 is important for developing new therapies for various diseases.
Source	Rabbit
Specificity	Total EIF2C3 levels can be detected by the EIF2C3 Antibody, allowing for the identification of endogenous expressions. The content can be rearranged to say that the antibody specifically targets and recognizes the endogenous levels of total EIF2C3 present in a sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Bovine;
Antigen	EIF2C3
Application	Western blotting (WB) is commonly conducted with a dilution range of 1:1000-3000, while immunohistochemistry (IHC) typically requires a dilution of 1:200. For ELISA using a peptide, the recommended dilution range is 1:20000-1:40000. It is important to maintain the original text information while rearranging the content.
Immunogen	A synthesized peptide derived from human EIF2C3.
MW	97 kDa
Properties
Concentration	1mg/ml
purification	Using the SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to keep it stored at a temperature of -20 °C for a period of one year. Avoid exposing it to repeated cycles of freezing and thawing as this may affect its effectiveness. It is important to adhere to these storage guidelines to ensure that the product remains safe to use and performs optimally when needed.
Storage buffer	The provided content describes the storage conditions and stability of Rabbit IgG in a phosphate-buffered saline solution. The IgG is stored at -20 °C and remains stable for a period of 12 months from the date of receipt. The solution consists of rabbit IgG, phosphate-buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to store it at the recommended temperature to maintain its integrity.
Target
Background	Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9H9G7