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Rabbit Anti-DP-2 Polyclonal Antibody#abs138053

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Description

Catalog-specification	Delivery time	USD price
abs138053-100ug	1-2 Weeks	301.0
abs138053-50ug	1-2 Weeks	201.0

Overview
catalog	abs138053
Other names	TFDP2, also known as E2F dimerization partner 2 or DP2, is a transcription factor that plays a crucial role in regulating gene expression. It forms a dimer with E2F transcription factors, specifically E2F1, E2F2, and E2F3, to activate or repress target gene transcription. TFDP2 is encoded by the TFDP2 gene in humans. The TFDP2 protein functions as a regulatory subunit for E2F transcription factors, enhancing their DNA-binding activity and promoting transcriptional activation. It plays a vital role in cell cycle progression and is involved in the regulation of genes required for DNA replication and cell division. Mutations or dysregulation of TFDP2 have been implicated in various diseases and conditions, including cancer. Overexpression of TFDP2 has been observed in several cancer types and is associated with increased cell proliferation and tumor growth. In summary, TFDP2 is a crucial transcription factor that interacts with E2F proteins to modulate gene expression and regulate cell cycle progression. Its dysregulation can have significant implications in disease development and progression, particularly in cancer.
Source	Rabbit
Specificity	The DP-2 Antibody is capable of detecting total DP-2 present in the body at its natural levels. The antibody is designed to target and recognize the endogenous levels of DP-2 in the body, which makes it a highly reliable tool for scientific research and experimentation. By using this antibody, researchers can gain valuable insights into the functions and interactions of DP-2 in various biological processes and systems, paving the way for new discoveries and breakthroughs in the field of biomedicine.
Species Reactivity	Human;Mouse;Rat
Antigen	DP-2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human DP-2.
MW	49 kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, an effective peptide affinity chromatography technique was employed to purify the antiserum. Attention was given to maintaining the original information while rearranging the content in a highly similar manner.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the material at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the material to multiple cycles of freezing and thawing as this can compromise its quality. Remember to follow these guidelines carefully to ensure the integrity of the material over time.
Storage buffer	The provided substance is Rabbit IgG dissolved in phosphate buffered saline (pH 7.4) containing 150mM NaCl. It further contains 0.02% sodium azide and 50% glycerol. The suggested storage condition is at -20 °C. The substance remains stable for a period of 12 months starting from the day it is received.
Target
Background	Stimulating E2F-dependent transcription, the TFDP2 protein binds to DNA in partnership with other E2F family members and acts on the E2 recognition site found in the promoter region of multiple genes that play key roles in regulating the cell cycle or DNA replication. By working together, the TFDP2:E2F complex governs the progression of the cell cycle from the G1 to the S phase. The E2F1:DP complex, on the other hand, is involved in both cell growth and cell death. Additionally, TFDP2 blocks adipocyte differentiation by inhibiting CEBPA from binding to its target gene promoters (PubMed:20176812).
Tissue specificity	High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.
Posttranslational modification	Ser-24 is probably phosphorylated by CDK2.
Celluar localization	Mitochondrion;Nucleus;
UniPort	Q14188