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Rabbit Anti-COLEC12 Polyclonal Antibody#abs139685

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Description

Catalog-specification	Delivery time	USD price
abs139685-100ug	1-2 Weeks	301.0
abs139685-50ug	1-2 Weeks	201.0

Overview
catalog	abs139685
Other names	Collectin placenta 1 (CL P1), also known as CL-P1 or CLP1, is a protein encoded by the COL12_HUMAN gene. It is a member of the collectin subfamily (COLEC 12) and is involved in various biological processes. CL P1, also referred to as colec12 or colec12, is a collectin-12 protein found in the placenta. It is also known as hCL P1 or hCL-P1 and is associated with nurse cell scavenger receptor 2 (NSR2). Additionally, it is classified as scavenger receptor class A member 4 (SCARA4) and scavenger receptor with C-type lectin (SRCL). The function and structure of CL P1 make it an important component in cellular processes.
Source	Rabbit
Specificity	Detecting total COLEC12 levels in the body is achievable with COLEC12 Antibody, as it is designed to target and identify endogenous COLEC12 protein. To generate similar content, the information can be rearranged to describe that the antibody specifically recognizes and binds to COLEC12 present in the body, enabling researchers to detect the total levels of this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	COLEC12
Application	The recommended dilution for Western blotting is 1:1000-3000, while for IHC it is 1:200. When using ELISA with a peptide substrate, a dilution of 1:20000-1:40000 is recommended. These dilution guidelines are based on the original text information and should be followed carefully to obtain optimal results. Is there anything else I can assist you with?
Immunogen	A synthesized peptide derived from human COLEC12.
MW	82 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed to conduct peptide affinity chromatography for the purification of the antiserum. Let me create a text that is highly similar to the original content by reorganizing the information provided.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store the item at a temperature of -20 °C for a duration of one year. To maintain its quality, it is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	The Rabbit IgG solution comes in a phosphate buffered saline, with pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal storage, it is recommended to keep the solution at a temperature of -20 °C, where it can remain stable for up to 12 months from the date of receipt. Please be sure to follow these storage guidelines to ensure the longevity and effectiveness of the solution.
Target
Background	Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Tissue specificity	Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q5KU26