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Rabbit Anti-CYR61 Polyclonal Antibody#abs135770

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Description

Catalog-specification	Delivery time	USD price
abs135770-100ug	1-2 Weeks	301.0
abs135770-50ug	1-2 Weeks	201.0

Overview
catalog	abs135770
Description	Cyr61 is a protein that is secreted and has the ability to bind to heparin. It is encoded by an immediate-early gene that is stimulated by growth factors, and it tends to attach to the connective tissue and extracellular matrix. This protein is part of the CCN family of regulators that are associated with angiogenesis and vasculogenesis, alongside CTGF and Fisp12 (the mouse Cyr61 homolog). In terms of its effects on angiogenesis, Cyr61 is known to bind to Integrin aV/b3 receptors on the cell surface, where it encourages cell adhesion and migration while promoting DNA synthesis in vascular endothelial cells. As vessels grow and wounds heal, the expression of Cyr61 tends to increase. Cyr61 can also be found in various types of tumors, where it promotes their growth and can serve as an indicator of tumor progression. Additionally, Cyr61 is associated with chondrocyte differentiation.
Other names	CYR61, also known as CCN family member 1, is a cysteine-rich protein that plays an important role in angiogenesis and wound healing. It is also involved in various cellular processes such as cell adhesion, migration, and proliferation. CYR61 is a member of the CCN family of proteins, which are named after their three initial members: Cyr61, CTGF, and Nov. CYR61 is a heparin-binding protein that has been shown to interact with multiple growth factors, including insulin-like growth factors (IGFs). It functions as an IGF-binding protein, specifically as IGFBP-10, and has been shown to regulate IGF activity. CYR61 is expressed in a variety of tissues, including bone, cartilage, and skin. In addition to its role in tissue repair and development, CYR61 has also been implicated in various diseases, including cancer. It has been shown to promote tumor growth and metastasis by enhancing angiogenesis and promoting cell proliferation and survival. Therefore, CYR61 has emerged as a potential therapeutic target for cancer treatment. Overall, CYR61 is a multifaceted protein that plays a crucial role in various physiological and pathological processes. Its complex interactions with growth factors and other cellular components make it an intriguing target for further research and therapeutic development.
Source	Rabbit
Specificity	The CYR61 Antibody is capable of detecting the total level of endogenous CYR61. To create similar content, one can rephrase the original text by stating that the antibody reacts to CYR61 proteins present in the body. It enables researchers to measure the extent of total CYR61 expression in cells using specific immunodetection methods.
Species Reactivity	Human
Antigen	CYR61
Application	The dilutions for western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) they range from 1:50 to 1:200, for immunofluorescence (IF) they range from 1:100 to 1:500, and for ELISA (peptide) the dilutions range from 1:20000 to 1:40000. It is important to note that the dilution ratios may vary depending on the specific experiment and the desired level of detection.
Immunogen	A synthesized peptide derived from human CYR61.
MW	42kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	O00622