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Rabbit Anti-Cubilin Polyclonal Antibody#abs133253

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Description

Catalog-specification	Delivery time	USD price
abs133253-100ug	1-2 Weeks	301.0
abs133253-50ug	1-2 Weeks	201.0

Overview
catalog	abs133253
Other names	The intrinsic factor-cobalamin receptor, also known as cubilin or intestinal intrinsic factor receptor, is a large protein with a molecular weight of 460 kDa. It is encoded by the CUBN gene and is involved in the absorption of cobalamin (vitamin B12) and other nutrients in the intestine. Cubilin is a multifunctional protein that also plays a role in the reabsorption of proteins in the kidney. Mutations in the CUBN gene can lead to megaloblastic anemia type 1, a rare genetic disorder characterized by low levels of vitamin B12 and other nutrients. The full-length precursor of cubilin undergoes post-translational processing to generate the mature receptor protein. In addition to its physiological functions, cubilin has potential diagnostic and therapeutic applications for various diseases.
Source	Rabbit
Specificity	The total Cubilin levels, both endogenous and exogenous, can be accurately detected using the Cubilin Antibody.
Species Reactivity	Human
Predictive reaction species	Dog
Antigen	Cubilin
Application	The recommended dilution for Western blot (WB) is between 1:1000 and 1:3000. For immunohistochemistry (IHC), the suggested dilution is 1:200. When performing ELISA using a peptide, it is advisable to dilute it at a range of 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human Cubilin.
MW	399kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain quality, store for one year at -20 °C. Prevent exposure to repeated freezing and thawing cycles. It is important to ensure that the original text is completely rephrased and a highly similar content is generated.
Storage buffer	The provided information states that Rabbit IgG should be stored at -20 °C in a solution of phosphate buffered saline with a pH of 7.4. The solution also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This storage condition ensures the stability of the Rabbit IgG for a period of 12 months from the date of receipt.
Target
Background	Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
Tissue specificity	Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
Posttranslational modification	The precursor is cleaved by a trans-Golgi proteinase furin. The result is a propeptide cleaved off.N-glycosylated.
Celluar localization	Cytosol;Endoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus;Lysosome;Plasma Membrane;
UniPort	O60494