Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-SCN11A Polyclonal Antibody#abs139449

Please note that the price provided is only for your reference. For detailed pricing information, we kindly ask you to contact our sales representative, Vecent. Western blot analysis SCN11A using 293 whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs139449-100ug	1-2 Weeks	301.0
abs139449-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For detailed pricing information, we kindly ask you to contact our sales representative, Vecent.

Overview
catalog	abs139449
Other names	Nav1.9 or SCN11A, also known as PN5 or SNS2, is a sodium channel protein involved in peripheral nerve function. It plays a crucial role in sensory neurons and is encoded by the SCN12A gene. The Nav1.9 channel is responsible for generating action potentials and is a vital component of the nervous system. Understanding the function and regulation of Nav1.9 can provide valuable insights into sensory processing and pain perception. This sodium channel voltage-gated type XI alpha subunit is essential for the proper functioning of the nervous system. Additionally, the Nav1.9 channel is closely related to the Nav1.9 voltage-gated sodium channel, SCNBA_HUMAN, and the sodium channel protein type XII alpha polypeptide. Overall, Nav1.9 plays a significant role in maintaining electrical excitability in sensory nerves.
Source	Rabbit
Specificity	The SCN11A Antibody is capable of detecting total SCN11A levels present within the body. This detection occurs in a manner that is responsive to the endogenous levels of SCN11A.
Species Reactivity	Human
Predictive reaction species	Pig;Sheep;Bovine;Horse;Rabbit
Antigen	SCN11A
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SCN11A.
MW	205 kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, we employed peptide affinity chromatography as a method to purify the antiserum. We ensured that the generated content is based on the original text information, but presented in a significantly different manner, as per your request.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Tissue specificity	Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
Posttranslational modification	Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9UI33